WormMine: GOTerm GO:0035267 NuA4 histone acetyltransferase complex GO

• Namespace: cellular_component
• Obsolete: false
• Description: A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).

0 Cross References

1 Data Sets

• GO Annotation data set

1 Ontology

• Name: GO

39 Ontology Annotations

19 Parents

Identifier	Name	Description
GO:1902494	catalytic complex	A protein complex which is capable of catalytic activity.
GO:0032991	protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
GO:0005575	cellular_component	A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0005622	intracellular anatomical structure	A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
GO:0110165	cellular anatomical structure	A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:0043226	organelle	Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0043229	intracellular organelle	Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0043228	membraneless organelle	Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
GO:0043232	intracellular membraneless organelle	Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
GO:0000785	chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
GO:0000123	histone acetyltransferase complex	A protein complex that possesses histone acetyltransferase activity.
GO:0031248	protein acetyltransferase complex	A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule.
GO:0005694	chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GO:1990234	transferase complex	A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).
GO:1902493	acetyltransferase complex	A protein complex which is capable of acetyltransferase activity.
GO:0140535	intracellular protein-containing complex	A protein-containing complex located intracellularly.
GO:0043189	H4/H2A histone acetyltransferase complex	A multisubunit complex that catalyzes the acetylation of histones H4 and H2A.
GO:0035267	NuA4 histone acetyltransferase complex	A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
GO:1902562	H4 histone acetyltransferase complex	A protein complex which is capable of H4 histone acetyltransferase activity.

19 Relations

Relationship	Parent Term . Identifier	Child Term . Identifier
is_a	GO:0043189	GO:0035267
is_a	GO:0032991	GO:0035267
is_a	GO:1902562	GO:0035267
part of	GO:0043232	GO:0035267
is_a	GO:1902494	GO:0035267
is_a	GO:0140535	GO:0035267
is_a	GO:1902493	GO:0035267
part of	GO:0043226	GO:0035267
part of	GO:0043228	GO:0035267
is_a	GO:0000123	GO:0035267
part of	GO:0110165	GO:0035267
part of	GO:0043229	GO:0035267
part of	GO:0005622	GO:0035267
part of	GO:0000785	GO:0035267
is_a	GO:0005575	GO:0035267
part of	GO:0005575	GO:0035267
is_a	GO:1990234	GO:0035267
part of	GO:0005694	GO:0035267
is_a	GO:0031248	GO:0035267

2 Synonyms

• Name: TIP60 histone acetylase complex
• Type: synonym

• Name: TIP60 histone acetyltransferase complex
• Type: synonym