WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0043223 cytoplasmic SCF ubiquitin ligase complex GO

Namespace  cellular_component Obsolete  false
Description  A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

1 Ontology Annotations

Annotation Extension Qualifier
part_of(GO:0005737)|part_of(GO:0005737) part_of

13 Parents

Identifier Name Description
GO:1902494 catalytic complex A protein complex which is capable of catalytic activity.
GO:0032991 protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
GO:0005737 cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0005622 intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
GO:0110165 cellular anatomical structure A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:1990234 transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).
GO:0140535 intracellular protein-containing complex A protein-containing complex located intracellularly.
GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
GO:0000153 cytoplasmic ubiquitin ligase complex A ubiquitin ligase complex found in the cytoplasm.
GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
GO:0019005 SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
GO:0043223 cytoplasmic SCF ubiquitin ligase complex A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

15 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0019005 GO:0043223
is_a GO:0019005 GO:0043223
is_a GO:0000153 GO:0043223
part of GO:0005737 GO:0043223
is_a GO:0140535 GO:0043223
is_a GO:1990234 GO:0043223
is_a GO:0031461 GO:0043223
is_a GO:0032991 GO:0043223
is_a GO:1902494 GO:0043223
part of GO:0005622 GO:0043223
part of GO:0005575 GO:0043223
part of GO:0110165 GO:0043223
is_a GO:0000151 GO:0043223
is_a GO:0005575 GO:0043223
part of GO:0005737 GO:0043223

3 Synonyms

Name Type
cytoplasmic cullin complex synonym
cytoplasmic Skp1/Cul1/F-box protein complex synonym
cytoplasmic SCF complex synonym