WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0043494 CLRC complex GO

Namespace  cellular_component Obsolete  false
Description  An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

25 Parents

Identifier Name Description
GO:1902494 catalytic complex A protein complex which is capable of catalytic activity.
GO:0032991 protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0005622 intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
GO:0110165 cellular anatomical structure A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:0140513 nuclear protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.
GO:0043227 membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0005654 nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
GO:0031974 membrane-enclosed lumen The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
GO:0031981 nuclear lumen The volume enclosed by the nuclear inner membrane.
GO:0070013 intracellular organelle lumen An organelle lumen that is part of an intracellular organelle.
GO:0043233 organelle lumen The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
GO:1990234 transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).
GO:0140535 intracellular protein-containing complex A protein-containing complex located intracellularly.
GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
GO:0000152 nuclear ubiquitin ligase complex A ubiquitin ligase complex found in the nucleus.
GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
GO:0080008 Cul4-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
GO:0034708 methyltransferase complex A protein complex that possesses methyltransferase activity.
GO:0035097 histone methyltransferase complex A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.
GO:0043494 CLRC complex An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi.

25 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0035097 GO:0043494
is_a GO:0000152 GO:0043494
is_a GO:0080008 GO:0043494
is_a GO:1990234 GO:0043494
part of GO:0031981 GO:0043494
part of GO:0043229 GO:0043494
is_a GO:0034708 GO:0043494
part of GO:0110165 GO:0043494
part of GO:0031974 GO:0043494
is_a GO:0140513 GO:0043494
part of GO:0005654 GO:0043494
part of GO:0043227 GO:0043494
is_a GO:0140535 GO:0043494
part of GO:0043226 GO:0043494
part of GO:0005575 GO:0043494
part of GO:0043233 GO:0043494
part of GO:0043231 GO:0043494
part of GO:0070013 GO:0043494
is_a GO:0031461 GO:0043494
is_a GO:0032991 GO:0043494
is_a GO:1902494 GO:0043494
part of GO:0005634 GO:0043494
part of GO:0005622 GO:0043494
is_a GO:0000151 GO:0043494
is_a GO:0005575 GO:0043494

4 Synonyms

Name Type
Clr4-Rik1-Cul4 complex synonym
Rik1 E3 ubiquitin ligase complex synonym
CLRC ubiquitin ligase complex synonym
Rik1-E3 ubiquitin ligase complex synonym