WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0046849 bone remodeling GO

Namespace  biological_process Obsolete  false
Description  The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

4 Parents

Identifier Name Description
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0032501 multicellular organismal process Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
GO:0048771 tissue remodeling The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.
GO:0046849 bone remodeling The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.

18 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0046849 GO:0043932
part of GO:0046849 GO:0043932
regulates GO:0046849 GO:0045124
part of GO:0046849 GO:0045453
regulates GO:0046849 GO:0045779
negatively regulates GO:0046849 GO:0045779
regulates GO:0046849 GO:0045780
is_a GO:0048771 GO:0046849
is_a GO:0032501 GO:0046849
is_a GO:0008150 GO:0046849
regulates GO:0046849 GO:0046850
regulates GO:0046849 GO:0046850
negatively regulates GO:0046849 GO:0046851
negatively regulates GO:0046849 GO:0046851
regulates GO:0046849 GO:0046851
positively regulates GO:0046849 GO:0046852
positively regulates GO:0046849 GO:0046852
regulates GO:0046849 GO:0046852

1 Synonyms

Name Type
bone remodelling synonym