WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0046776 symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I GO

Namespace  biological_process Obsolete  false
Description  A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC class I transmembrane protein complex. One mechanism of suppression is by direct inhibition of host tapasin, a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, some viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

12 Parents

Identifier Name Description
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0044419 biological process involved in interspecies interaction between organisms Any process evolved to enable an interaction with an organism of a different species.
GO:0051701 biological process involved in interaction with host An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.
GO:0044403 biological process involved in symbiotic interaction A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts.
GO:0044003 symbiont-mediated perturbation of host process A process in which a symbiont alters or subverts a biological process in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO:0035821 modulation of process of another organism A process in which an organism effects a change in a biological process in another organism.
GO:0052553 symbiont-mediated perturbation of host immune response A process in which a symbiont alters or subverts the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO:0052031 symbiont-mediated perturbation of host defense response A process in which a symbiont interferes with the ability of the host to mount a defense in response to its presence. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO:0052562 symbiont-mediated suppression of host immune response A process in which a symbiont interferes with, inhibits or disrupts the normal execution of an immune response of the host organism. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO:0039504 symbiont-mediated suppression of host adaptive immune response A process by which a symbiont inhibits or disrupts the normal execution of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
GO:0039588 symbiont-mediated suppression of host antigen processing and presentation A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC protein complex.
GO:0046776 symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC class I transmembrane protein complex. One mechanism of suppression is by direct inhibition of host tapasin, a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, some viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response.

11 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0039588 GO:0046776
is_a GO:0044419 GO:0046776
is_a GO:0039504 GO:0046776
is_a GO:0008150 GO:0046776
is_a GO:0051701 GO:0046776
is_a GO:0044403 GO:0046776
is_a GO:0035821 GO:0046776
is_a GO:0052031 GO:0046776
is_a GO:0052553 GO:0046776
is_a GO:0052562 GO:0046776
is_a GO:0044003 GO:0046776

7 Synonyms

Name Type
suppression by virus of host tapasin activity synonym
suppression by virus of host MHC class I cell surface presentation synonym
GO:0039591 alt_id
suppression by virus of MHC class I cell surface presentation in host synonym
inhibition of host MHC class I molecule presentation by virus synonym
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I synonym
negative regulation by virus of MHC class I cell surface presentation synonym