WormMine: Gene WBGene00227069

• WormBase Gene ID: WBGene00227069
• Gene Name: Bma-smg-6
• Sequence Name: Bm6808
• Organism: Brugia malayi
• Automated Description: Is affected by ivermectin based on RNA-seq studies. Is predicted to encode a protein with the following domains: Tetratricopeptide-like helical domain superfamily; PIN domain; PIN-like domain superfamily; DNA/RNA-binding domain, Est1-type; Telomerase activating protein Est1; Est1 DNA/RNA binding domain; Est1/Ebs1-like; and Telomerase activating protein Est1, N-terminal. Is an ortholog of C. elegans smg-6. In C. elegans, smg-6 is involved in embryonic genitalia morphogenesis; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and regulatory ncRNA-mediated post-transcriptional gene silencing.
• Biotype: SO:0001217
• Genetic Position: :±

1 Organism

• Name: Brugia malayi
• Taxon Id: 6279

0 Synonyms

Genomics

2 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Bm6808b.1	Bm6808b.1		[unknown]
Transcript:Bm6808a.1	Bm6808a.1		[unknown]

Other

2 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Bm6808a	Bm6808a		[unknown]
CDS:Bm6808b	Bm6808b		[unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

1 Data Sets

• WormBaseAcedbConverter

0 Downstream Intergenic Region

3 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_M120_vs_F120
	Transcripts that showed significantly decreased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_F120_vs_F30
	Transcripts that showed significantly decreased expression after 5 days of 1uM ivermectin exposure.	Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method).	WBPaper00049974:ivermectin_1uM_5-day_downregulated

0 Expression Patterns

0 GO Annotation

0 Homologues

0 Locations

0 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term