1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00001851 | hif-1 | F38A6.3 | Caenorhabditis elegans |
| WormBase ID | WBStrain00040824 | CGC Received | 2002-03-01 |
| Genotype | hif-1(ia4) V. | Laboratory | CGC |
| Made By | WBPerson496 | Mutagen | EMS |
| Name | ZG31 | Outcrossed | x9 |
| Remark | Healthy and fertile in standard lab conditions, but unable to adapt to 1% oxygen. When hif-1(+) animals are incubated in1% oxygen, >94% will complete embryogenesis and larval development. In contrast, hif-1(ia4) mutants exhibit 66% embryonic lethality and 9% larval lethality in 1% oxygen. The requirement of hif-1 is alleviated if the oxygen level is increased to 2%. The ia4 mutation is a 1231 bp deletion of the second, third, and fourth exons, which encode much of the helix-loop-helix and PAS domains. Analysis of ESTs suggests that there are at least 4 alternatively spliced hif-1 transcripts. The ia4 deletion introduces a frameshift and a premature stop in the three longest forms. | Species | Caenorhabditis elegans |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00001851 | hif-1 | F38A6.3 | Caenorhabditis elegans |
