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WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0060308 GTP cyclohydrolase I regulator activity GO

Namespace  molecular_function Obsolete  false
Description  Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

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0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

15 Parents

Identifier Name Description
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2.
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0005515 protein binding Binding to a protein.
GO:0098772 molecular function regulator activity A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.
GO:0019899 enzyme binding Binding to an enzyme, a protein with catalytic activity.
GO:0030234 enzyme regulator activity Binds to and modulates the activity of an enzyme.
GO:0019238 cyclohydrolase activity Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring.
GO:0003933 GTP cyclohydrolase activity Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized.
GO:0003934 GTP cyclohydrolase I activity Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+.
GO:0044549 GTP cyclohydrolase binding Binding to a GTP cyclohydrolase.
GO:0060308 GTP cyclohydrolase I regulator activity Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

16 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0030234 GO:0060308
has part GO:0044549 GO:0060308
regulates GO:0003934 GO:0060308
regulates GO:0016814 GO:0060308
regulates GO:0019238 GO:0060308
regulates GO:0016810 GO:0060308
regulates GO:0016787 GO:0060308
regulates GO:0003824 GO:0060308
has part GO:0019899 GO:0060308
is_a GO:0098772 GO:0060308
is_a GO:0003674 GO:0060308
has part GO:0005515 GO:0060308
regulates GO:0003933 GO:0060308
regulates GO:0003674 GO:0060308
has part GO:0005488 GO:0060308
has part GO:0003674 GO:0060308

0 Synonyms