WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0070320 inward rectifier potassium channel inhibitor activity GO

Namespace  molecular_function Obsolete  false
Description  Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

37 Parents

Identifier Name Description
GO:0022890 inorganic cation transmembrane transporter activity Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
GO:0022857 transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0005215 transporter activity Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0008324 monoatomic cation transmembrane transporter activity Enables the transfer of cation from one side of a membrane to the other.
GO:0046873 metal ion transmembrane transporter activity Enables the transfer of metal ions from one side of a membrane to the other.
GO:0015075 monoatomic ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other.
GO:0015318 inorganic molecular entity transmembrane transporter activity Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon.
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0005515 protein binding Binding to a protein.
GO:0098772 molecular function regulator activity A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.
GO:0015267 channel activity Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
GO:0022803 passive transmembrane transporter activity Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged.
GO:0140678 molecular function inhibitor activity A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target.
GO:0099094 ligand-gated monoatomic cation channel activity Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
GO:0015276 ligand-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
GO:0005261 monoatomic cation channel activity Enables the energy-independent facilitated diffusion of a monoatomic cation through a transmembrane aqueous pore or channel.
GO:0005216 monoatomic ion channel activity Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
GO:0022836 gated channel activity Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.
GO:0022834 ligand-gated channel activity Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
GO:0005244 voltage-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
GO:0022832 voltage-gated channel activity Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
GO:0005267 potassium channel activity Enables the energy-independent facilitated diffusion of a potassium ion through a transmembrane aqueous pore or channel.
GO:0015079 potassium ion transmembrane transporter activity Enables the transfer of potassium ions (K+) from one side of a membrane to the other.
GO:0005242 inward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
GO:0005249 voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
GO:0022843 voltage-gated monoatomic cation channel activity Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
GO:0099106 ion channel regulator activity Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.
GO:0016247 channel regulator activity Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.
GO:0141108 transporter regulator activity Binds to and modulates the activity of a transporter.

52 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
negatively regulates GO:0005242 GO:0070320
is_a GO:0019870 GO:0070320
regulates GO:0015075 GO:0070320
regulates GO:0015079 GO:0070320
negatively regulates GO:0022857 GO:0070320
negatively regulates GO:0022890 GO:0070320
regulates GO:0022803 GO:0070320
is_a GO:0141110 GO:0070320
is_a GO:0015459 GO:0070320
regulates GO:0005267 GO:0070320
regulates GO:0005261 GO:0070320
regulates GO:0015318 GO:0070320
negatively regulates GO:0022843 GO:0070320
negatively regulates GO:0046873 GO:0070320
negatively regulates GO:0015075 GO:0070320
negatively regulates GO:0022803 GO:0070320
negatively regulates GO:0005249 GO:0070320
regulates GO:0003674 GO:0070320
negatively regulates GO:0005244 GO:0070320
regulates GO:0022857 GO:0070320
regulates GO:0005215 GO:0070320
regulates GO:0005216 GO:0070320
is_a GO:0003674 GO:0070320
negatively regulates GO:0015318 GO:0070320
is_a GO:0008200 GO:0070320
regulates GO:0008324 GO:0070320
regulates GO:0022890 GO:0070320
is_a GO:0140678 GO:0070320
negatively regulates GO:0015079 GO:0070320
negatively regulates GO:0015276 GO:0070320

0 Synonyms