WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0070578 RISC-loading complex GO

Namespace  cellular_component Obsolete  false
Description  A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

3 Ontology Annotations

Annotation Extension Qualifier
  part_of
  part_of
  part_of

7 Parents

Identifier Name Description
GO:1902494 catalytic complex A protein complex which is capable of catalytic activity.
GO:0032991 protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0140535 intracellular protein-containing complex A protein-containing complex located intracellularly.
GO:1902555 endoribonuclease complex A protein complex which is capable of endoribonuclease activity.
GO:1905348 endonuclease complex A protein complex which is capable of endonuclease activity.
GO:0070578 RISC-loading complex A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.

6 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:1902555 GO:0070578
is_a GO:1902494 GO:0070578
is_a GO:0140535 GO:0070578
is_a GO:0005575 GO:0070578
is_a GO:1905348 GO:0070578
is_a GO:0032991 GO:0070578

3 Synonyms

Name Type
microRNA loading complex synonym
RLC synonym
miRLC synonym