WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

Strain :

WormBase ID  WBStrain00006437 CGC Received  2012-04-16
Genotype  sec-5(pk2357)/mIn1 [dpy-10(e128) mIs14] II. Laboratory  CGC
Made By  WBPerson516 Name  DV2689
Remark  Heterozygotes segregate wild-type GFP+ heterozygotes, GFP+ Dpy, and sec-5 homozygotes (scrawny, small broods, abnormal gut appearance) sec-5 is homozygous maternal-effect lethal; M+Z- animals produce a few dead L1-L2 stage larvae with Vab defects. Pick GFP+ wild-type to maintain. Based upon phenotype, pk2357 is a strong loss-of-function, but likely not a null allele; molecular lesion produces a premature stop at position 389. Reference: Frische EW, et al. EMBO J. 2007 Dec 12;26(24):5083-92. [NOTE: This strain was previously described as carrying pk2358, but pk2357 is the correct allele. Both pk2357 and pk2358 cause the same nonsense (amber) change.] Species  Caenorhabditis elegans

2 Alleles

Public Name
e128
pk2357

1 Data Sets

Name URL
WormBaseAcedbConverter  

2 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00001072 dpy-10 T14B4.7 Caenorhabditis elegans
WBGene00004752 sec-5 T23G7.4 Caenorhabditis elegans