WormMine: Gene HGNC:12502

• WormBase Gene ID: HGNC:12502
• Gene Name: Sumo1
• Organism: Homo sapiens
• Automated Description: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
• Biotype: SO:0001217
• Genetic Position: :±

1 Organism

• Name: Homo sapiens
• Taxon Id: 9606

0 Synonyms

Genomics

0 Transcripts

Other

0 CDSs

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

2 Data Sets

• WormBaseAcedbConverter
• Panther orthologue and paralogue predictions

0 Downstream Intergenic Region

0 Expression Clusters

0 Expression Patterns

0 GO Annotation

1 Homologues

0 Locations

0 Ontology Annotations

2 Regulates Expr Cluster

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Genes showing > 1.5-fold up-regulated expression (p<0.001) both in aex-3::His-SUMO-1 and myo-4::His-SUMO-1 C. elegans.	The Linear Models for Microarray Data (Limma) package using linear model fitting for statistical testing with empirical Bayes variance smoothing procedure were applied to detection of differentially expressed genes in aex-3::His-SUMO-1 and myo-4::His-SUMO-1 nematodes when compared to N2. The obtained p values were corrected for multiple testing using Benjamini and Hochberg false discovery rate procedure. For downstream analysis, genes with FDR corrected p < 0.001 were used including 1,805 probe sets from aex-3::His-SUMO-1 versus N2 comparison (899 under- and 906 overexpressed) and 1,342 probe sets from myo-4::His-SUMO-1 versus N2 comparison (774 under and 568 overexpressed).	WBPaper00038060:SUMO-1_upregulated
	Genes showing < 0.5-fold down-regulated expression (p < 0.001) both in aex-3::His-SUMO-1 or myo-4::His-SUMO-1 C. elegans.	The Linear Models for Microarray Data (Limma) package using linear model fitting for statistical testing with empirical Bayes variance smoothing procedure were applied to detection of differentially expressed genes in aex-3::His-SUMO-1 and myo-4::His-SUMO-1 nematodes when compared to N2. The obtained p values were corrected for multiple testing using Benjamini and Hochberg false discovery rate procedure. For downstream analysis, genes with FDR corrected p < 0.001 were used including 1,805 probe sets from aex-3::His-SUMO-1 versus N2 comparison (899 under- and 906 overexpressed) and 1,342 probe sets from myo-4::His-SUMO-1 versus N2 comparison (774 under and 568 overexpressed).	WBPaper00038060:SUMO-1_downregulated

0 Sequence

1 Sequence Ontology Term