WormBase Gene ID
|
RGD:61867 | Gene Name | Casp9 |
| Organism | Rattus norvegicus | Automated Description | Enables cysteine-type peptidase activity. Involved in several processes, including glial cell apoptotic process; response to estradiol; and response to ischemia. Predicted to be located in nucleus. Predicted to be part of apoptosome and caspase complex. Predicted to be active in cytosol and mitochondrion. Used to study pre-malignant neoplasm. Biomarker of several diseases, including bronchopulmonary dysplasia; cerebrovascular disease (multiple); heart disease (multiple); kidney disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9); PARTICIPATES IN intrinsic apoptotic pathway; endometrial cancer pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (+)-taxifolin; (-)-anisomycin; (-)-citrinin. |
| Biotype | SO:0001217 | Genetic Position | :± |
