WormBase Gene ID
|
RGD:2536 | Gene Name | Ednrb |
| Organism | Rattus norvegicus | Automated Description | Enables endothelin receptor activity and type 1 angiotensin receptor binding activity. Involved in several processes, including blood vessel diameter maintenance; cGMP-mediated signaling; and positive regulation of penile erection. Located in nuclear membrane. Used to study several diseases, including artery disease (multiple); lymphopenia; megacolon (multiple); portal hypertension; and type 2 diabetes mellitus. Biomarker of asthma; hepatopulmonary syndrome; and hypertension. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg syndrome; Waardenburg syndrome type 4A; and asthma. Orthologous to human EDNRB (endothelin receptor type B); PARTICIPATES IN calcium/calmodulin dependent kinase signaling pathway; endothelin signaling pathway; inflammatory response pathway; INTERACTS WITH (R)-noradrenaline; (S)-colchicine; (S)-nicotine. |
| Biotype | SO:0001217 | Genetic Position | :± |
