WormBase Gene ID
|
SGD:S000004589 | Gene Name | NDI1 |
| Organism | Saccharomyces cerevisiae | Automated Description | NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy |
| Biotype | SO:0001217 | Genetic Position | :± |
