WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0098855 HCN channel complex GO

Namespace  cellular_component Obsolete  false
Description  A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

15 Parents

Identifier Name Description
GO:0032991 protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0110165 cellular anatomical structure A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:0071944 cell periphery The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures.
GO:0098796 membrane protein complex Any protein complex that is part of a membrane.
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:1990351 transporter complex A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells.
GO:1902495 transmembrane transporter complex A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other.
GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0098797 plasma membrane protein complex Any protein complex that is part of the plasma membrane.
GO:0034703 cation channel complex An ion channel complex through which cations pass.
GO:0034702 monoatomic ion channel complex A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective monoatomic ion transport down its electrochemical gradient.
GO:0034705 potassium channel complex An ion channel complex through which potassium ions pass.
GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
GO:0098855 HCN channel complex A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart.

15 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0008076 GO:0098855
is_a GO:0034705 GO:0098855
is_a GO:0098796 GO:0098855
part of GO:0005575 GO:0098855
is_a GO:0098797 GO:0098855
part of GO:0005886 GO:0098855
part of GO:0110165 GO:0098855
part of GO:0016020 GO:0098855
is_a GO:0005575 GO:0098855
is_a GO:1990351 GO:0098855
is_a GO:0032991 GO:0098855
part of GO:0071944 GO:0098855
is_a GO:1902495 GO:0098855
is_a GO:0034703 GO:0098855
is_a GO:0034702 GO:0098855

18 Synonyms

Name Type
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex synonym
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 tetramer synonym
GO:1990759 alt_id
GO:1990746 alt_id
HCN2 channel complex synonym
HCN1 channel complex synonym
HCN4 channel complex synonym
HCN3 channel complex synonym
K/Na hyperpolarization-activated cyclic nucleotide-gated channel 1 complex synonym
K/Na hyperpolarization-activated channel 3 complex synonym
K/Na hyperpolarization-activated cyclic nucleotide-gated channel 4 complex synonym
K/Na hyperpolarization-activated cyclic nucleotide-gated channel 2 complex synonym
potassium/sodium hyperpolarization-activated channel 3 complex synonym
K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex synonym
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 complex synonym
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 complex synonym
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 complex synonym
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 tetramer synonym