WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0120113 cytoplasm to vacuole targeting by the NVT pathway GO

Namespace  biological_process Obsolete  false
Description  A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

34 Parents

Identifier Name Description
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0051179 localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0051234 establishment of localization Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0008152 metabolic process A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
GO:0043170 macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0005622 intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
GO:0110165 cellular anatomical structure A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:0019538 protein metabolic process The chemical reactions and pathways involving a protein. Includes protein modification.
GO:0051649 establishment of localization in cell Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
GO:0051641 cellular localization A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.
GO:0046907 intracellular transport The directed movement of substances within a cell.
GO:0071705 nitrogen compound transport The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0033036 macromolecule localization Any process in which a macromolecule is transported to, or maintained in, a specific location.
GO:0051604 protein maturation Any process leading to the attainment of the full functional capacity of a protein.
GO:0008104 protein localization Any process in which a protein is transported to, or maintained in, a specific location.
GO:0070727 cellular macromolecule localization Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
GO:0015031 protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0045184 establishment of protein localization The directed movement of a protein to a specific location.
GO:0006508 proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
GO:0016485 protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
GO:0006605 protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
GO:0072594 establishment of protein localization to organelle The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.
GO:0033365 protein localization to organelle A process in which a protein is transported to, or maintained in, a location within an organelle.
GO:0006623 protein targeting to vacuole The process of directing proteins towards the vacuole, usually using signals contained within the protein.
GO:0007034 vacuolar transport The directed movement of substances into, out of or within a vacuole.

42 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
has part GO:0006624 GO:0120113
is_a GO:0006623 GO:0120113
has part GO:0009987 GO:0120113
is_a GO:0009987 GO:0120113
occurs in GO:0005575 GO:0120113
is_a GO:0033036 GO:0120113
part of GO:0008150 GO:0120113
is_a GO:0008150 GO:0120113
is_a GO:0071705 GO:0120113
is_a GO:0045184 GO:0120113
part of GO:0008104 GO:0120113
is_a GO:0051649 GO:0120113
has part GO:0044238 GO:0120113
is_a GO:0072665 GO:0120113
is_a GO:0072666 GO:0120113
has part GO:0016485 GO:0120113
is_a GO:0051641 GO:0120113
has part GO:0008152 GO:0120113
part of GO:0051179 GO:0120113
is_a GO:0006810 GO:0120113
has part GO:0008150 GO:0120113
has part GO:0019538 GO:0120113
occurs in GO:0005622 GO:0120113
is_a GO:0007034 GO:0120113
is_a GO:0008104 GO:0120113
occurs in GO:0110165 GO:0120113
is_a GO:0033365 GO:0120113
is_a GO:0070727 GO:0120113
has part GO:0006508 GO:0120113
part of GO:0009987 GO:0120113

1 Synonyms

Name Type
protein localization by the Nbr1-mediated vacuolar targeting pathway synonym