WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:1990265 platelet-derived growth factor complex GO

Namespace  cellular_component Obsolete  false
Description  A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD).

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

4 Parents

Identifier Name Description
GO:0032991 protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0036454 growth factor complex A protein complex that has growth factor activity.
GO:1990265 platelet-derived growth factor complex A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD).

4 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0036454 GO:1990265
is_a GO:0032991 GO:1990265
is_a GO:0005575 GO:1990265
has part GO:1990265 GO:1990270

6 Synonyms

Name Type
PDGF complex synonym
PDGF-DD dimer synonym
PDGF-AB dimer synonym
PDGF-AA dimer synonym
PDGF-CC dimer synonym
PDGF-BB dimer synonym