WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:1990332 Ire1 complex GO

Namespace  cellular_component Obsolete  false
Description  A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

28 Parents

Identifier Name Description
GO:1902494 catalytic complex A protein complex which is capable of catalytic activity.
GO:0032991 protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
GO:0005737 cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0005622 intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
GO:0110165 cellular anatomical structure A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:0043227 membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:1990234 transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).
GO:0140535 intracellular protein-containing complex A protein-containing complex located intracellularly.
GO:0098796 membrane protein complex Any protein complex that is part of a membrane.
GO:0012505 endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
GO:0031984 organelle subcompartment A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle.
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0031090 organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
GO:1902555 endoribonuclease complex A protein complex which is capable of endoribonuclease activity.
GO:1905348 endonuclease complex A protein complex which is capable of endonuclease activity.
GO:1902554 serine/threonine protein kinase complex A protein complex which is capable of protein serine/threonine kinase activity.
GO:0061695 transferase complex, transferring phosphorus-containing groups A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
GO:1902911 protein kinase complex A protein complex which is capable of protein kinase activity.
GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
GO:0140534 endoplasmic reticulum protein-containing complex A protein complex that is part of an endoplasmic reticulum.
GO:0098827 endoplasmic reticulum subcompartment A distinct region of the endoplasmic reticulum.
GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.
GO:1990332 Ire1 complex A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.

28 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0140534 GO:1990332
part of GO:0005789 GO:1990332
is_a GO:0098796 GO:1990332
is_a GO:1902554 GO:1990332
is_a GO:1902555 GO:1990332
part of GO:0012505 GO:1990332
is_a GO:1990234 GO:1990332
part of GO:0031984 GO:1990332
is_a GO:1902911 GO:1990332
is_a GO:1905348 GO:1990332
part of GO:0042175 GO:1990332
is_a GO:0005575 GO:1990332
part of GO:0043229 GO:1990332
part of GO:0031090 GO:1990332
part of GO:0043227 GO:1990332
is_a GO:0140535 GO:1990332
part of GO:0005622 GO:1990332
part of GO:0110165 GO:1990332
part of GO:0043226 GO:1990332
is_a GO:1902494 GO:1990332
part of GO:0005783 GO:1990332
part of GO:0098827 GO:1990332
is_a GO:0032991 GO:1990332
part of GO:0043231 GO:1990332
part of GO:0016020 GO:1990332
part of GO:0005737 GO:1990332
is_a GO:0061695 GO:1990332
part of GO:0005575 GO:1990332

6 Synonyms

Name Type
ER-bound kinase/endoribonuclease (RNase), inositol-requiring enzyme-1 synonym
ERN1 complex synonym
Ire1 complex dimer synonym
Ire1 complex homodimer synonym
Ire1 complex homooligomer synonym
IRE1 dimer synonym