8 Parents
| Identifier | Name | Description |
|---|---|---|
| GO:0032991 | protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| GO:0005737 | cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| GO:0005575 | cellular_component | A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). |
| GO:0005622 | intracellular anatomical structure | A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. |
| GO:0110165 | cellular anatomical structure | A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses. |
| GO:0140535 | intracellular protein-containing complex | A protein-containing complex located intracellularly. |
| GO:0101031 | protein folding chaperone complex | A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. |
| GO:1990565 | HSP90-CDC37 chaperone complex | A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins. |
8 Relations
| Relationship |
Parent Term . Identifier |
Child Term . Identifier |
|---|---|---|
| is_a | GO:0101031 | GO:1990565 |
| part of | GO:0005737 | GO:1990565 |
| is_a | GO:0032991 | GO:1990565 |
| is_a | GO:0005575 | GO:1990565 |
| part of | GO:0005622 | GO:1990565 |
| part of | GO:0110165 | GO:1990565 |
| part of | GO:0005575 | GO:1990565 |
| is_a | GO:0140535 | GO:1990565 |
