WormMine: AnatomyTerm WBbt:0005300

• Definition: neuron with cell body associated with the ventral nerve cord.
• Name: ventral cord neuron
• Primary Identifier: WBbt:0005300
• Synonym: ventral cord motoneuron

55 Children

Definition	Name	Synonym	Primary Identifier
Neuron class of six motoneurons in the ventral cord, which innervate ventral body muscles and the vm2 muscles of the vulva.	VC neuron		WBbt:0005304
Ventral cord motor neuron, innervates ventral body muscles	VB8	lineage name: P7.aaap	WBbt:0004629
Ventral cord motor neuron, innervates ventral body muscles	VB9	lineage name: P8.aaap	WBbt:0004627
Ventral cord motor neuron, innervates ventral body muscles	VB10	lineage name: P9.aaap	WBbt:0004625
Ventral cord motor neuron, innervates ventral body muscles	VB11	lineage name: P10.aaap	WBbt:0004623
Ventral cord motor neuron, innervates ventral body muscles	VB4	lineage name: P3.aaap	WBbt:0004638
Ventral cord motor neuron, innervates ventral body muscles	VB5	lineage name: P4.aaap	WBbt:0004637
Ventral cord motor neuron, innervates ventral body muscles	VB6	lineage name: P5.aaap	WBbt:0004633
Ventral cord motor neuron, innervates ventral body muscles	VB7	lineage name: P6.aaap	WBbt:0004631
Ventral cord motor neuron, innervates ventral body muscles	VB3	lineage name: P2.aaap	WBbt:0004639
Ventral cord motor neurons, innervate dorsal muscles	DB7	lineage name: ABprppaappp	WBbt:0004840
Ventral cord motor neurons, innervate dorsal muscles	DB3	lineage name: ABprpaaaapp	WBbt:0004844
Ventral cord motor neurons, innervate dorsal muscles	DB4	lineage name: ABprpappapp	WBbt:0004843
Ventral cord motor neurons, innervate dorsal muscles	DB5	lineage name: ABplpapappp	WBbt:0004842
Ventral cord motor neurons, innervate dorsal muscles	DA2	lineage name: ABplppapapa	WBbt:0004869
Ventral cord motor neurons, innervate dorsal muscles	DB6	lineage name: ABplppaappp	WBbt:0004841
Ventral cord motor neurons, innervate dorsal muscles	DA6	lineage name: ABplpppaaap	WBbt:0004861
Ventral cord motor neurons, innervate dorsal muscles	DA7	lineage name: ABprpppaaap	WBbt:0004859
Ventral cord motor neurons, innervate dorsal muscles	DA3	lineage name: ABprppapapa	WBbt:0004867
Ventral cord motor neurons, innervate dorsal muscles	DA4	lineage name: ABplppapapp	WBbt:0004865
Ventral cord motor neurons, innervate dorsal muscles	DA5	lineage name: ABprppapapp	WBbt:0004863
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS6	lineage name: P6.apa	WBbt:0003910
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS4	lineage name: P4.apa	WBbt:0003912
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS5	lineage name: P5.apa	WBbt:0003911
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS3	lineage name: P3.apa	WBbt:0003923
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS2	lineage name: P2.apa	WBbt:0003924
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS9	lineage name: P9.apa	WBbt:0003907
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS10	lineage name: P10.apa	WBbt:0003906
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS7	lineage name: P7.apa	WBbt:0003909
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS8	lineage name: P8.apa	WBbt:0003908

0 Expression Clusters

812 Expression Patterns

• Primary Identifier: Expr4896
• Remark: Picture: Fig. 5C.
• Pattern: Punc-103::GFP transcriptional fusion was expressed in many neurons in the nervous system, including some motor neurons along the ventral cord.

• Primary Identifier: Expr4889
• Remark: Picture: Fig. 4.
• Pattern: pQC106, with the 3.0 kb promoter, showed expression in the same cells as pQC105 and also in rectal cells, vulva cells, the spermatheca-uterine valve and in body wall muscle cells and neurons of the ventral nerve cord.

• Primary Identifier: Expr4870
• Pattern: A-class motor neuron: expressed in embryo; enriched in larva (1.6). Neuronal expression include: All ventral cord motor neurons, head neurons, touch neurons. Also expressed in other cells: Intestine, anal depressor, head muscle. Pan-neuronal: expressed in embryo and larva.

• Primary Identifier: Expr4863
• Pattern: A-class motor neuron: enriched in embryo (3.0) and larva (2.8). Neuronal expression include: Bright in anterior ventral cord neurons, weak and mosaic in posterior ventral cord. Also expressed in other cells: Pharyngeal/intestinal valves, hypodermis. Pan-neuronal: expressed in embryo; enriched in larva (1.8).

• Primary Identifier: Expr4852
• Pattern: A-class motor neuron: enriched in larva (1.8); not expressed in embryo. Neuronal expression include: All ventral cord motor neurons, head and tail neurons, touch neurons. Also expressed in other cells: Body muscle, anal depressor, sphincter muscle? Excretory gland cells?. Pan-neuronal: enriched in larva (3.2); not expressed in embryo.

• Primary Identifier: Expr4853
• Pattern: A-class motor neuron: enriched in embryo (3.5) and larva (5.1). Neuronal expression include: All ventral cord neurons. Pan-neuronal: enriched in larva (2.1); not expressed in embryo.

• Primary Identifier: Expr4856
• Pattern: A-class motor neuron: expressed in embryo; enriched in larva (1.9). Neuronal expression include: L2 -- DA, VA, VB, VD, bright in touch neurons, head and tail neurons L3 -- all ventral cord motor neurons. Pan-neuronal: expressed in embryo; enriched in larva (5.9).

• Primary Identifier: Expr4857
• Pattern: A-class motor neuron: enriched in embryo (4.5) and larva (4.8). Neuronal expression include: All ventral cord neurons, head and tail neurons. Pan-neuronal: expressed in embryo; enriched in larva (3.5).

• Primary Identifier: Expr4841
• Pattern: A-class motor neuron: expressed in embryo; not expressed in larva. Neuronal expression include: All ventral cord motor neurons, head and tail neurons, PLN. Also expressed in other cells: Pharyngeal muscle, vulval muscle, anal depressor, hypodermis. Pan-neuronal: enriched in embryo (1.8); not expressed in larva.

• Primary Identifier: Expr4842
• Pattern: A-class motor neuron: enriched in embryo (2.9); not expressed in larva. Neuronal expression include: Weak in head and tail neurons, ventral cord. Also expressed in other cells: Pharynx, sheath cells, distal tip cell. Pan-neuronal: enriched in embryo (1.9); expressed in larva.

• Primary Identifier: Expr4843
• Pattern: A-class motor neuron: expressed in larva; enriched in embryo (2.0). Neuronal expression include: Bright in head neurons, few tail neurons. weak in all ventral cord motor neurons. Touch neurons, PDE. Also expressed in other cells: Intestine, head muscle, pharyngeal muscle, hypodermis, distal tip cell. Pan-neuronal: expressed in larva; enriched in embryo(3.0).

• Primary Identifier: Expr4844
• Pattern: A-class motor neuron: expressed in larva; enriched in embryo (2.4). Neuronal expression include: All ventral cord motor neurons, head and tail neurons. Pan-neuronal: expressed in larva; enriched in embryo (2.3).

• Primary Identifier: Expr4840
• Pattern: A-class motor neuron: expressed in embryo; not expressed in larva. Neuronal expression include: All ventral cord motor neurons, head and tail neurons, touch neurons. Also expressed in other cells: Intestine, vulval muscle, pharyngeal muscle, anal depressor, body muscle. Pan-neuronal: enriched in embryo (1.8); not expressed in larva.

• Primary Identifier: Expr4820
• Remark: Picture: Figure S1.
• Pattern: Expressed in head neurons, ventral-cord motor neurons, body-wall muscle, vulval muscle, stomatointestinal muscle, anal-depressor muscle, tail neurons, etc.

• Primary Identifier: Expr4826
• Remark: Picture: fig. S3 A.
• Pattern: A transgene containing the sel-10 promoter driving green fluorescent protein (GFP) labeled a subset of neurons including the HSNL, which suggests that sel-10 is expressed in the HSNL. sel-10 promoter driven GFP is widely expressed in body wall muscles (not consistent though), intestine(not consistent), pharynx, distal tip cell, spermatheca, and within nervous system, it is expressed in HSNs, some ventral cord neurons, a bunch of unidentified head neurons and a few tail neurons. --Pers. Comm. from Mei Ding 11-20-07.

• Primary Identifier: Expr4819
• Remark: Picture: Figure S1.
• Pattern: Expressed in head neurons, ventral-cord motor neurons, body-wall muscle, vulval muscle, stomatointestinal muscle, anal-depressor muscle, tail neurons, etc.

• Primary Identifier: Expr4911
• Remark: Picture: Fig S5.
• Pattern: A transcriptional fusion of the unc-50 promoter to GFP is expressed in all cell types throughout development. unc-50::gfp expression was seen in the head of adult hermaphrodite. Expression is seen in the pharyngeal muscle, head neurons, and epidermis. Expression is also present in the gut, ventral cord motor neurons, and epidermal seam cells. In the mid body region expression is seen in the gut, seam cells, uterus, vulva muscles, and distal tip cell. In the tail region unc-50 expression can be detected in the epidermis and enteric muscles.

• Primary Identifier: Expr4387
• Pattern: GPN-1::GFP was expressed in a smaller number of neuroblasts prior to epidermal enclosure. In later embryogenesis GPN-1::GFP was expressed strongly in the developing pharynx and in ventral cord neurons.

• Primary Identifier: Expr4381
• Pattern: Expressed in AVA, AVB, DVA, I5, RID, RIM, PVQ, SAA, SIA, SIB, SMB(?), SMD, ventral cord motor neurons, some unidentified neurons in the head. Also expressed head muscles (weak), body wall muscles (weak).

• Primary Identifier: Expr4340
• Remark: No detailed description on expression pattern in other life stages.
• Pattern: acr-8::GFP was strongly expressed in all body muscle cells as well as in anal and vulval muscles and ventral cord motor neurons. Expression was visible in the embryo.

• Primary Identifier: Expr4403
• Pattern: Strong and consistent expression was observed in a limited number of neurons in the head and tail and coelomocytes. Weaker and/or inconsistent expression of TTX-7::EGFP was detected in nerve cord motor neurons, intestine, and somatic gonad. The head neurons expressing ttx-7::EGFP include AFD and RIA neurons. Also expressed in ASH, ASE, ASJ, AWC, ADF, ADL, ASI, ASK, AWB, VNC motor neurons, etc.
• Subcellular Localization: TTX-7::EGFP was diffusely expressed in the cytoplasm and was not localized to any specific subcellular compartment.

• Primary Identifier: Expr4282
• Pattern: Transgenic animals expressing SMI-1::GFP demonstrated strong expression throughout development, up to and including adulthood. SMI-1 was expressed in the gut at all stages through development. In addition, fluorescence was also detected in a subset of nerve cells in the head, in ventral nerve cord cell bodies and also in body-wall muscle cells. A high level of fluorescence was observed in vulval abnormalities, moulting defects and sterility.
• Subcellular Localization: Expressed in ventral nerve cord cell bodies

• Primary Identifier: Expr4248
• Pattern: LIS-1 is expressed in all classes of neurons (GABA, cholinergic, glutamatergic) within the ventral cord of C. elegans.

• Primary Identifier: Expr4249
• Pattern: The NUD-2 fusion protein was expressed within neurons of the ventral cord as well as the pharynx, seam cells of the hypodermis, and in the vulva muscle cells.

• Primary Identifier: Expr4471
• Remark: No detailed description on expression pattern in other life stage.
• Pattern: Expressed in ventral nerve cord at L2/L3, L4 and adult, pair of head muscle cells at L2/L3, ventral motor neurons from L2 to adult.

• Primary Identifier: Expr4472
• Remark: No detailed description on expression pattern in other life stage.
• Pattern: Expressed in ventral nerve cord at L2/L3, L4 and adult, pair of head muscle cells at L2/L3 and L4, ventral motor neurons from L2 to adult.

• Primary Identifier: Expr4556
• Pattern: Expressed in touch receptor neurons, ventral cord neurons and the nerve ring in the head.
• Subcellular Localization: Expressed in the cell bodies and processes of neurons.

• Primary Identifier: Expr4557
• Pattern: Expressed in touch receptor neurons, ventral cord neurons and the nerve ring in the head.
• Subcellular Localization: Expressed in the cell bodies and processes of neurons.

• Primary Identifier: Expr4547
• Reporter Gene: For dre-1::gfp, a 4 kb promoter was amplified with primers 5' -GGTACCCGAGGGGACATCGAGATAG-3' and 5' -GGTACCTTCCTGGCCAACCAGAGAC-3' and was cloned into Fire vector L3781 (BA 279). The dre-1 ORF and the dre-1 3' UTR region were amplified with primers 5' -GCTAGCATGTCGTCCTCTTCGTCAC-3' and 5' -ACTAGTTACTTACTCCACTCCACACAG-3' and were cloned into BA279 (BA280). Lines containing this construct included dhEx346 and dhIs442. To obtain the full-length promoter construct, authors substituted the promoter from BA279 with a 12.3 kb promoter by using primers 5' -GCGGCCGCGTTGCACACAAAACATTATTATTTTCTTTCTCTT-3' and 5' -TACGTATCTCGTCCCTGAGATCTCTCATTT-3' (BA508). Resulting lines containing this array included dhEx443 and dhEx452. --precise ends.
• Pattern: First detected by midembryogenesis, expression was most prominent in epidermal and intestinal cells. By the 1.5-fold stage of embryogenesis, expression was additionally detected in neurons and other cells. During larval and adult stages, DRE-1::GFP was most visible in epidermal seam cells and hypodermis. Expression was high in larvae and low in adults. In addition, DRE-1 was strongly expressed in the P epidermal blast cells and descendents that give rise to the vulva. Weak expression was seen in the somatic gonad, including the gonadoblasts, the anchor cell, dtcs, and occasionally adult spermatheca and uterus. Notably, with another construct (dhEx346, 4 kb promoter, 4 kb coding region), dtc expression was stronger and commenced by mid-L3. In the musculature, DRE-1 was seen in the pharynx, anal depressor, sex muscles, and body wall muscles. Finally, DRE-1 was detected in neurons of the head, tail, ventral cord, and periphery.
• Subcellular Localization: Generally, DRE-1::GFP was localized to both the nucleus and cytoplasm, and it was broadly expressed, including in phenotypically affected tissues.

• Primary Identifier: Expr4542
• Pattern: Expressed in Many head neurons, ventral cord and tail neurons, body-wall muscle, hypodermis, somatic gonad, intestine.

0 Life Stages

1 Parents

Definition	Name	Synonym	Primary Identifier
neuron of the somatic nervous system.	somatic neuron	body neuron	WBbt:0006752