WormMine: ExpressionPattern Expr2945

• Pattern: tbx-8 is expressed in three different cell types in the embryo, gut, muscle and hypodermis. The earliest embryonic expression was detected in the E lineage gut cell precursors Ea and Ep at the beginning of gastrulation (100 minutes after first cleavage). Expression was seen in the direct descendents of Ea and Ep but was not obvious later in E lineage nuclei. tbx-8 was subsequently expressed in muscle and hypodermal cells. The expression of tbx-8 was stronger in dorsal hypodermal nuclei. This is particularly evident in embryos that have been co-stained with LIN-26 and GFP antibodies. Expression could also be seen in dorsal hypodermal nuclei undergoing contralateral migration following cellular intercalation, and in lateral hypodermal cells during dorsal intercalation, although expression in lateral hypodermal cells at this stage was weaker. Expression in lateral hypodermal (seam) cells could also be seen later in embryogenesis until the 1.5-fold stage. No expression was observed in ventral hypodermal cells. The earliest detectable muscle cell expression was seen around the 400-cell stage, when muscle cells were present as two rows on the left and right sides of the embryo.
• Primary Identifier: Expr2945
• Remark: No detailed description on expression pattern in other life stages.
• Subcellular Localization: In all cases expression was found to be nuclear.

8 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Epidermal layer.	hypodermis	epidermis	WBbt:0005733
Contractile cell that makes up muscle tissue.	muscle cell		WBbt:0003675
embryonic cell	Ep		WBbt:0006612
embryonic cell	Ea		WBbt:0006733
embryonic cell	Epl		WBbt:0006000
embryonic cell	Eal		WBbt:0006441
embryonic cell	Ear		WBbt:0006370
embryonic cell	Epr		WBbt:0006547

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006545	tbx-8	T07C4.2	Caenorhabditis elegans

1 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003