| Primary Identifier | Expr2278 | Remark | Wild-type rac-2 and rac-2(G12V)-coding regions displayed indistinguishable localization, and gfp::rac-2(G12V) caused dominant effects on PDE development. Expression of GFP from a transgene that contained a frameshift between the gfp- and rac-2-coding regions failed to accumulate at the cell margins and in the nerve ring and instead was uniformly distributed in the cytoplasm, indicating that RAC-2 sequences mediate accumulation of GFP::RAC-2 at the plasma membrane, presumably via C-terminal CAAX motif. |
| Subcellular Localization | Animals harboring the unc-115::gfp::rac-2 transgene showed expression of GFP::RAC-2 that accumulate at the cell margins of neuroblasts and neurons as well as in the nerve ring. Nerve ring accumulation suggests that GFP::RAC-2 localized to the plasma membranes of axons. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses. | neuron | neurone | WBbt:0003679 |
| the most extensive region of neuropil in the animal, consists of a large toroidal bundle of processes. | nerve ring | circumpharyngeal nerve ring | WBbt:0006749 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00004287 | rac-2 | K03D3.10 | Caenorhabditis elegans |
