| Pattern | RPM-1 expression was seen predominantly in the nervous system. The specificity of the RPM-1 antibody was confirmed by staining rpm-1 mutant animals. | Primary Identifier | Expr7897 |
| Remark | Picture: Figure 1. | Subcellular Localization | Dynamin is associated with synaptic vesicles and is required for endocytosis. DYN-1::GFP and RPM-1 showed an adjacent, nonoverlapping, distribution. Thus, endogenous RPM-1 is localized in a region that is close to, but not overlapping with, synaptic vesicle release and recycling domains. In the nerve ring and nerve cords, endogenous expression of RPM-1 was mostly punctate, with varying degrees of intensity. No signal was detected in the cell bodies. Within the nerve ring and dorsal and ventral nerve cords, anti-RPM-1 signal was found to be close to, but not overlap with, those of anti-RIM or anti-SNT-1. Measurement of the average distance between RPM-1 and RIM puncta in the dorsal cords showed that 75% of RPM-1 puncta were within 250 nm of a RIM puncta (n = 100 RPM-1 puncta). Anti-SNT-1 or anti-RIM staining showed a string of fluorescent puncta spaced evenly along the SAB axons, while anti-RPM-1 staining was seen adjacent to those of anti-RIM or anti-SNT-1. Moreover, anti-RPM-1 signal showed a graded pattern such that higher immunofluorescent intensity was consistently detected at the anterior ends of the SAB axons. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| Complement of nervous tissue (neurones, nerves, receptors and support cells) serving to detect, relay and coordinate information about an animal`s internal and external environments and to initiate and integrate its effector responses and activities. | nervous system | WBbt:0005735 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00004457 | rpm-1 | C01B7.6 | Caenorhabditis elegans |
