WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

Expression Pattern :

Pattern  FAX-1 protein was detected in the nuclei of wild-type embryonic neurons beginning at mid-embryogenesis (approximately 350 min), the time at which most embryonic neurons differentiate, and through all larval and adult stages. For most neurons, the expression pattern was static throughout larval and adult stages. The pattern, location, and number of neurons that expressed FAX-1 in the embryo were also consistent with the postembryonic expression. This analysis confirmed the strong expression of FAX-1 in the nuclei of AVK interneurons previously reported using different methods. In addition, FAX-1 protein accumulated to high levels in the nuclei of AVA, AVB, and AVE bilateral interneuron pairs of the head. Strong FAX-1 expression was also identified in the RIC bilaterally-paired interneurons. FAX-1 was strongly expressed in two additional bilateral neuron pairs located just ventral to the AVA/AVE neurons. These neurons are SIBD and either SIBV or SMBV. Strong expression of FAX-1 protein was observed in the M4 motorneuron of the pharynx. Weak and variable FAX-1 expression was observed in the AIY interneuron pair of young larva, but no expression in adults. The only other neuron that accumulated FAX-1 was the unpaired DVA interneuron of the tail. FAX-1 protein was not observed at any stage in any of the 69 ventral midline motorneurons that mediate body movements. FAX-1 protein expressed in a dynamic fashion in the nuclei of two non-neuronal cell types during larval development. FAX-1 protein was detected in the paired distal tip cells (DTCs) of the hermaphrodite somatic gonad of L2 through L4 stage larvae and two pairs of vulval cells in L4 hermaphrodite larvae. During the time of FAX-1 expression, both of these cell types are undergoing either long range migration (DTCs) or complex local morphogenesis (vulval cells). Primary Identifier  Expr3762
Remark  In contrast to the findings of fax-1::gfp expression analysis, no accumulation of FAX-1 protein was observed in neurons of the retro-vesicular ganglion of the head or preanal ganglion of the tail, the CEP sensory neurons, or the dorsal rectal cell. Either the gfp analysis yielded these cells as false positives due to transgenic artifacts, or the gfp reporter analysis was more sensitive than anti-FAX-1 antibody. The alternative explanation that the anti-FAX-1 antibody only detects some isoforms of FAX-1 is unlikely because cDNA analysis has revealed no evidence of alternative splicing outside of the unconserved N-terminus and because the antibodies we used were polyclonal and raised to the entire known FAX-1 protein. Subcellular Localization  Expressed in the nuclei.
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23 Anatomy Terms

Definition Name Synonym Primary Identifier
female genital. vulva   WBbt:0006748
Anterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad anterior distal tip cell gon herm dtc A WBbt:0004520
Posterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad posterior distal tip cell gon herm dtc P WBbt:0004506
Amphid interneuron AIYL lineage name: ABplpapaaap WBbt:0003963
Amphid interneuron AIYR lineage name: ABprpapaaap WBbt:0003961
Ring interneuron RICL lineage name: ABplppaaaapp WBbt:0003941
Ring interneuron RICR lineage name: ABprppaaaapp WBbt:0003940
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIBDL lineage name: ABplppaaaaa WBbt:0004981
Ventral cord interneuron, synapses onto VA, DA, and AS motor neurons; formerly called alpha AVAL lineage name: ABalppaaapa WBbt:0003870
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIBDR lineage name: ABprppaaaaa WBbt:0004979
Ventral cord interneuron, synapses onto VA, DA, and AS motor neurons; formerly called alpha AVAR lineage name: ABalaappapa WBbt:0003869
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIBVL lineage name: ABplpapaapp WBbt:0004978
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIBVR lineage name: ABprpapaapp WBbt:0004977
Neuron class of one ring interneuron, cell body in dorsorectal ganglion, has a large vesicle-filled process in ring. DVA lineage name: ABprppppapp WBbt:0004823
Ventral cord interneuron, synapses onto VB and DB motor neurons; formerly called beta. AVBL lineage name: ABplpaapaap WBbt:0003868
Ventral cord interneuron, synapses onto VB and DB motor neurons; formerly called beta. AVBR lineage name: ABprpaapaap WBbt:0003867
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally SMBVL lineage name: ABalpapappp WBbt:0004974
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally SMBVR lineage name: ABarappappp WBbt:0004973
Ring and ventral cord interneuron. AVKL lineage name: ABplpapapap WBbt:0003845
Ring and ventral cord interneuron. AVKR lineage name: ABprpapapap WBbt:0003844
Neuron class of one pharyngeal motorneuron. M4 neuron lineage name: MSpaaaaaa WBbt:0004467
Ventral cord interneuron, like AVD but outputs restricted to anterior cord. AVEL lineage name: ABalpppaaaa WBbt:0003864
Ventral cord interneuron, like AVD but outputs restricted to anterior cord. AVER lineage name: ABpraaaaaaa WBbt:0003863

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00001400 fax-1 F56E3.4 Caenorhabditis elegans

8 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The stage that begins when a C.elegans individual is fully-developed and has reached maturity. adult Ce WBls:0000041
  The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch. L3 larva Ce WBls:0000035
  The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch. L2 larva Ce WBls:0000027
  The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch. L4 larva Ce WBls:0000038
  The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch. L1 larva Ce WBls:0000024
  The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching. embryo Ce WBls:0000003
  The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo. fully-elongated embryo Ce WBls:0000021
  The C. elegans life stage spanning 350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation until elongation is over. elongating embryo Ce WBls:0000015