WormMine: ExpressionPattern Expr8352

• Pattern: Both antibodies, which recognize LAD-2L but not LAD-2S, revealed LAD-2 localization at the plasma membrane of 14 neurons and their associated axons. These 14 neurons include the SAA, SMD, SDQ, PLN, and ALN neurons, which is in agreement with the LAD-2 expression pattern inferred from a transcriptional GFP reporter (See Expr8353). lad-2 expression, which can be detected when these neurons are born, persists throughout and after axon extension. Indeed, embryonically born ALN and SMD neurons as well as SDQL, SDQR, and PLN neurons, which are born in the L1 larval stage, show lad-2 expression when they are born. This expression continues during axon migration, which is completed postembryonically, and persists in these neurons and their axons throughout adulthood.
• Primary Identifier: Expr8352
• Remark: LAD-2 staining is not detected in lad-2 mutant animals, which indicates antibody specificity. Picture: Figure 2A, 2E.
• Subcellular Localization: plasma membrane

12 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Interneuron, associated with PLM	PLNL	lineage name: TL.pppap	WBbt:0004102
Interneuron, associated with PLM	PLNR	lineage name: TR.pppap	WBbt:0004098
Ant. lateral interneuron, process projects into ring	SDQR	lineage name: QR.pap	WBbt:0004991
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally	SMDVR	lineage name: ABarappppaa	WBbt:0004969
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally	SMDDL	lineage name: ABplpapaaaa	WBbt:0004972
Ring interneuron, anteriorly projecting process that runs sublaterally	SAAVR	lineage name: ABprpaaaaaa	WBbt:0005001
Ring interneuron, anteriorly projecting process that runs sublaterally	SAADL	lineage name: ABalppapapa	WBbt:0005007
Ring interneuron, anteriorly projecting process that runs sublaterally	SAADR	lineage name: ABarapppapa	WBbt:0005005
Ring interneuron, anteriorly projecting process that runs sublaterally	SAAVL	lineage name: ABplpaaaaaa	WBbt:0005003
Posterior lateral interneuron, process projects into ring	SDQL	lineage name: QL.pap	WBbt:0004993
Neuron associated with ALM	ALNL	lineage name: ABplapappppap	WBbt:0003939
Neuron associated with ALM	ALNR	lineage name: ABprapappppap	WBbt:0003937

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00002243	lad-2	Y54G2A.25	Caenorhabditis elegans

6 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The stage that begins when a C.elegans individual is fully-developed and has reached maturity.		adult Ce	WBls:0000041
	The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch.		L3 larva Ce	WBls:0000035
	The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.		L2 larva Ce	WBls:0000027
	The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch.		L4 larva Ce	WBls:0000038
	The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.		L1 larva Ce	WBls:0000024
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003