1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00007278 | lab-1 | C03D6.6 | Caenorhabditis elegans |
| Primary Identifier | Expr8521 | Remark | Picture: Fig. 1D, 2A, 2B, 2D, 2E. Supplemental Fig. 3A,B. |
| Subcellular Localization | LAB-1 associates with chromosomes from entry into prophase I until the end of meiosis I. During pachytene, the LAB-1 signal intensifies and is observed as continuous tracks at the interface between homologous chromosomes, in a similar localization to that detected at this stage for the SC (the synaptonemal complex) component SYP-1. Strikingly, during late pachytene, LAB-1 and SYP-1 progressively acquire a reciprocal localization. Specifically, the LAB-1 signal is observed on chromosome regions where SYP-1 is lost, and in a reciprocal fashion, SYP-1 remains on regions where the LAB-1 signal is no longer apparent. Upon chromosome resolution, SYP-1 localization is restricted to the short arms of the bivalents at diakinesis, whereas LAB-1 is observed exclusively on the long arms. Moreover, while the SYP-1 signal is lost prior to the end of diakinesis, LAB-1 remains localized to chromosomes until homolog segregation at anaphase I. Closer examination of the long arm domain revealed a distinct ring-like structure formed by LAB-1 and REC-8 that presumably delineates the interface between sister chromatids. Furthermore, coimmunostaining of LAB-1 and SYP-1 revealed that SC disassembly in lab-1(tm1791) mutants, although completed by the end of diakinesis (~1 oocyte), is considerably delayed when compared with wild type. Thus, LAB-1 associates with the interchromatid domain harboring the cohesin complex on the bivalent and undergoes an unprecedented chromatin reorganization process in late prophase I nuclei that is essential for the correct kinetics of SC disassembly and the adoption of a long arm identity. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00007278 | lab-1 | C03D6.6 | Caenorhabditis elegans |
