WormMine: ExpressionPattern Expr1415

• Pattern: MES-2 is highly enriched in the germline and is located in the nuclei. All germ nuclei in the mitotic and meiotic regions are stained, with the exception of sperm. A maternal load of protein is seen in the nucleoplasm of oocytes; mature sperm lack detectable protein. Adult males also display staining in germ nuclei, which declines during spermatogenesis and is undetectable in sperm. The only adult somatic nuclei that contain detectable levels of MES-2 are those in the intestine. Staining in intestinal nuclei is extremely faint in some samples and undetectable in other samples. In early embryos, MES-2 is observed in the nuclei of all blastomeres. In blastomeres that lack an intact nuclear envelope because they are undergoing mitosis, MES-2 is predominantly cytoplasmic, but some MES-2 is clearly associated with the chromosomes. At progressively later stages of embryogenesis, the intensity of MES-2 staining in the nuclei of somatic cells decreases. Upon hatching, staining of MES-2 is significantly higher in the nuclei of the two primordial germ cells, Z2 and Z3, than in somatic nuclei. At later stages of larval development, MES-2 is oberved exclusively in the germline and localized in the nuclei.
• Primary Identifier: Expr1415
• Subcellular Localization: nuclei, nucleoplasm, cytoplasmic, associated with the chromosomes

4 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages.	intestine	gut	WBbt:0005772
cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes.	germ line	germline	WBbt:0005784
Germ line precursor cell	Z2	lineage name: P4.p	WBbt:0004576
Germ line precursor cell	Z3	lineage name: P4.a	WBbt:0004575

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00003220	mes-2	R06A4.7	Caenorhabditis elegans

1 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	All C. elegans development stages, including embryo, larva and adult stage.		all stages Ce	WBls:0000002