WormMine: ExpressionPattern Expr3986

• Pattern: Pgpdh-1::GFP expression was virtually undetectable under control conditions but showed dramatic up-regulation in the intestine and hypodermis in worms exposed to hypertonicity.
• Primary Identifier: Expr3986
• Remark: Pgpdh-1-GFP expression was proportional to the level of hypertonic stress, and the time course of expression correlated well with that of glycerol accumulation. Heat shock (30 centigrades), endoplasmic reticulum stress (10 ug/ml tunicamycin), cold (4 centigrades), and oxidative stress (230 uM juglone and 100% O2) failed to activate Pgpdh-1::GFP. These data demonstrate that Pgpdh-1::GFP specifically reports activation of signaling pathways required for glycerol synthesis and adaptation of C. elegans to hypertonic stress.

2 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages.	intestine	gut	WBbt:0005772
Epidermal layer.	hypodermis	epidermis	WBbt:0005733

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00009824	gpdh-1	F47G4.3	Caenorhabditis elegans

0 Life Stages