WormMine: ExpressionPattern Expr15142

• Pattern: We observed GFP::ZNFX-1 expression in the adult germline as well as in developing germ cells during all stages of embryonic and larval development. No GFP::ZNFX-1 expression was observed in somatic tissues. After fertilization, C. elegans zygotes undergo a series of asymmetric cell divisions in which germline determinants segregate with germline blastomeres. During embryonic development, ZNFX-1 foci were concentrated in, and segregated with, the germline blastomeres. In adult germ cells, GFP::ZNFX-1 was concentrated in foci that were distributed in a perinuclear pattern around nuclei. We conclude that znfx-1 encodes a germline-expressed protein that segregates with the germline and localizes to perinuclear foci in adult germ cells.GFP::ZNFX-1 and GFP::WAGO-4 colocalized with PGL-1::TagRFP in P1-P3 germline blastomeres, suggesting that ZNFX-1 and WAGO-4 are P granule factors.
• Primary Identifier: Expr15142

5 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes.	germ line	germline	WBbt:0005784
embryonic founder cell	Psub3	lineage name: P0.ppp	WBbt:0006875
embryonic founder cell	Psub1	lineage name: P0.p	WBbt:0006874
embryonic founder cell	Psub2	lineage name: P0.pp	WBbt:0006873
Embryonic founder cell of germ line	Psub4	lineage name: P0.pppp	WBbt:0004421

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00014208	znfx-1	ZK1067.2	Caenorhabditis elegans

0 Life Stages