WormMine: ExpressionPattern Expr1905

• Pattern: MES-4 is present in the distal, mitotic region of the germ line, barely detectable in the early- to mid-pachytene region, and up-regulated in later pachytene and in oocytes. In embryos, MES-4 is present in both somatic and germline nuclei until the 80- to 100-cell stage. Subsequently, MES-4 staining diminishes in somatic cells but persists in the primordial germ cells Z2 and Z3.
• Primary Identifier: Expr1905
• Subcellular Localization: MES-4 is localized to nuclei and associated with chromosomes. Staining in one-cell embryos revealed that one chromosome of each parental set of six lacks MES-4. In four-cell embryos two chromosomes in each diploid nucleus lack MES-4. MES-4 is also restricted to the autosomes in the adult hermaphrodite germ line. After the near-disappearance and then reappearance of MES-4 during pachytene, it associates with five bivalents but is lacking from one, presumably the X. Thus, MES-4 is off the Xs when X-linked oocyte genes become detectably expressed in late pachytene. MES-4 staining in male germ lines resembles that in hermaphrodites.

3 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes.	germ line	germline	WBbt:0005784
Germ line precursor cell	Z2	lineage name: P4.p	WBbt:0004576
Germ line precursor cell	Z3	lineage name: P4.a	WBbt:0004575

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00003222	mes-4	Y2H9A.1	Caenorhabditis elegans

6 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The stage that begins when a C.elegans individual is fully-developed and has reached maturity.		adult Ce	WBls:0000041
	The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch.		L3 larva Ce	WBls:0000035
	The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.		L2 larva Ce	WBls:0000027
	The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch.		L4 larva Ce	WBls:0000038
	The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.		L1 larva Ce	WBls:0000024
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003