WormMine: ExpressionPattern Expr13418

• Pattern: No XND-1 antibody staining was visible in <28-cell stage embryos; it was first detected in the cytoplasm and nucleus of P4. Chromatin association of XND-1 is readily apparent at this stage. This early embryo expression is consistent with mRNA expression data that indicated xnd-1 mRNA is maternally deposited and preferentially enriched in P4 (NEXTDB; http://nematode.lab.nig.ac.jp). We note that the in situ data suggests that xnd-1 mRNAs are found in all embryonic blastomeres, raising the possibility that post-transcriptional mechanisms repress xnd-1 both in the early embryo and in later, somatic blastomeres. Just prior to the division of P4, XND-1 localization became predominantly nuclear and remained chromatin-associated for the remainder of development and into the adult. No somatic expression was observed with the transgenes or by immunostaining, confirming our prior conclusion from genetic studies that xnd-1 function appears limited to the germ line (Wagner et al., 2010). Wild-type embryos showed XND-1 expression in P4 and its daughters, Z2 and Z3.
• Primary Identifier: Expr13418

4 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes.	germ line	germline	WBbt:0005784
The fourth (count from anterior-most) of twelve postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1.	P4		WBbt:0006773
Germ line precursor cell	Z2	lineage name: P4.p	WBbt:0004576
Germ line precursor cell	Z3	lineage name: P4.a	WBbt:0004575

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00001514	xnd-1	C05D2.5	Caenorhabditis elegans

1 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	All C. elegans development stages, including embryo, larva and adult stage.		all stages Ce	WBls:0000002