WormMine: ExpressionPattern Expr3116

• Pattern: Strong antibody staining was seen primarily in areas with dividing cells; i.e., the gonad and embryos.
• Primary Identifier: Expr3116
• Subcellular Localization: In the gonad, staining was bright in germline nuclei of the distal mitotic zone, dim in early meiotic prophase nuclei, and then bright again in late prophase nucleoplasm. Just before fertilization, KLP-19 concentrated on prophase chromosomes. During metaphase of meiosis I, staining concentrated slightly in the body of the spindle, more around the periphery of chromosomes, and most between homologous chromosomes. A similar pattern was seen in meiosis II. In embryos, during most of mitotic prophase, KLP-19 concentrated in nucleoplasm. In prometaphase, it concentrated slightly in the body of the spindle and more strongly around the periphery of chromosomes. In anaphase, it left chromosomes and concentrated in the spindle interzone. These dynamic patterns predict that KLP-19 functions in meiotic and mitotic spindles and suggest that, despite the lack of a recognizable DNA-binding motif, it can associate with chromosomes during prometaphase congression.

1 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes.	germ line	germline	WBbt:0005784

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00002229	klp-19	Y43F4B.6	Caenorhabditis elegans

2 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The stage that begins when a C.elegans individual is fully-developed and has reached maturity.		adult Ce	WBls:0000041
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003