| Primary Identifier | Expr10608 | Subcellular Localization | cpna-1 is significantly enriched or specific to body-wall muscle. CPNA-1 localizes to both M-lines and dense bodies, co-localizing with UNC-89 (M-lines), and with alpha-actinin (dense bodies). CPNA-1 co-localizes with the membrane proximal protein UNC-112, and therefore CPNA-1 is membrane-proximal in both dense bodies and M-lines. In addition, CPNA-1 and PAT-6 co-localize to both dense bodies and M-lines. This was shown with Anti-CPNA-1 antibodies and YFP tagged CPNA-1.CPNA-1 is close to the plasma membrane, at the same level as the ECM protein UNC-52 (perlecan), and the membrane proximal proteins UNC-112 and PAT-6, but also extending more deeply into the cell than these proteins. However, CPNA-1 does not extend as deeply into the cell as the M-line protein UNC- 89 (obscurin). CPNA-1 is observed in dense bodies both distal and proximal to the cell membrane, supporting the idea that some CPNA-1 molecules localize close to, or within the basal membrane of body wall muscle cells at integrin adhesion sites. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion. | body wall musculature | body muscle | WBbt:0005813 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00006495 | cpna-1 | F31D5.3 | Caenorhabditis elegans |
