WormMine: ExpressionPattern Expr699

• Pattern: Staining is first detected after fertilization in both the oocyte and sperm pronuclei shortly before the first mitotic division. After the first cleavage, the nuclei of both AB and P1 blastomeres appear to contain equivalent levels of the protein. During the first embryonic cell cycle, the protein appears to accumulate to much higher levels in the nucleus of P1 than in the AB nucleus. As AB and P1 enter mitosis, the protein is distributed throughout the cytoplasm. After the nuclei of the AB daughters re-form, both appear to have equivalent levels of the protein and similarly with the P1 daughters but at a much higher level.. During the second cell cycle the level of the protein increases in the nuclei of both P1 daughters. Late in the cell cycle the level of protein begins to decrease in both P1 daughters and in both AB daughters and in many embryos the two AB daughters have no detectable protein. After the third cleavage (8-cell stage), there is no detectable protein in any of the AB granddaughters but staining is detected throughout the P1 granddaughters. By the 12-cell stage, there is no staining in any blastomere. Peak levels of SKN-1 detected at 4-cell stage in EMS and P2. Little or no expression are detected in ABa and ABp.
• Primary Identifier: Expr699
• Remark: This information was extracted from published material (Archana Sharma-Oates, Andrew Mounsey and Ian A. Hope).

9 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Embryonic founder cell	MS	lineage name: P0.paa	WBbt:0004458
Embryonic founder cell	E	lineage name: P0.pap	WBbt:0004804
embryonic cell	ABa		WBbt:0005906
embryonic cell	ABp		WBbt:0005994
Embryonic founder cell	AB	AB blastomere	WBbt:0004015
embryonic cell	EMS		WBbt:0006876
embryonic founder cell	Psub3	lineage name: P0.ppp	WBbt:0006875
embryonic founder cell	Psub1	lineage name: P0.p	WBbt:0006874
embryonic founder cell	Psub2	lineage name: P0.pp	WBbt:0006873

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00004804	skn-1	T19E7.2	Caenorhabditis elegans

1 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The C. elegans life stage spanning 0-100min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 28 cells. From first cleavage until the start of gastrulation.		blastula embryo Ce	WBls:0000005