WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

Expression Pattern :

Pattern  The reporter construct (pKK63) is sufficient to drive GFP expression in the VPCs and their descendants as well as in the six VC motoneurons that innervate vulval muscles, which are likely to be co-regulated with vulval cells. When expression of egl-18::GFP is first detected in VPCs around the mid-L2 stage, all six VPCs are equally likely to express GFP. However, beginning at around the late-L2/early-L3 stage, until the VPCs divide in the mid-L3 stage, the expression in P5.p-P7.p is generally higher than in the other VPCs, and P6.p often shows the strongest expression. Expression persists in the descendants of P5.p-P7.p through the L4 stage, and P6.p descendants typically show stronger expression than descendants of P5.p and P7.p. This pattern is similar to that of lin-39 expression in the developing vulva. Primary Identifier  Expr2277
Remark  Similar vulval expression was observed when GFP was fused to the start codon of either egl-18 or elt-6 in a reporter containing ~8 kb of contiguous genomic sequence that includes this ~800 bp region, suggesting that the ~800 bp region is likely to be a vulval enhancer for both genes. As the expression levels and patterns of pKK63 showed substantial variability, even among chromosomal integrants of the transgene, the characterization of the spatial and temporal pattern of egl-18/elt-6::GFP expression is based on the composite pattern that emerged from examination of many animals. egl-18 = elt-5
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38 Anatomy Terms

Definition Name Synonym Primary Identifier
Neuron class of six motoneurons in the ventral cord, which innervate ventral body muscles and the vm2 muscles of the vulva. VC neuron   WBbt:0005304
  P6.p hermaphrodite   WBbt:0008125
descendent cell of post-embryonic blast cell P5, posterior, in hermaphrodite. P5.p hermaphrodite   WBbt:0008121
descendent cell of post-embryonic blast cell P4, posterior, in hermaphrodite. P4.p hermaphrodite   WBbt:0008117
descendent cell of post-embryonic blast cell P3, posterior in hermaphrodite. P3.p hermaphrodite   WBbt:0008112
  P8.p hermaphrodite   WBbt:0008133
  P7.p hermaphrodite   WBbt:0008129
adult vulval toroid cell, F, formed by fusion of precursors of lineage names P6.papl, P6.papr, P6.ppal and P6.ppar. vulF   WBbt:0006768
adult vulval toroid cell, E, formed by fusion of precursors of lineage names P6.paal, P6.paar, P6.pppl and P6.pppr. vulE   WBbt:0006767
cell, posteior daughter of P6.p P6.pp   WBbt:0006988
cell, anterior daughter of P6.p P6.pa   WBbt:0006987
cell, posterior descendent of P7.p P7.pp   WBbt:0006984
cell, anterior descendent of P7.p P7.pa   WBbt:0006983
post-embryonic cell of pedigree P5.pa P5.pa   WBbt:0007252
cell, anterior daughter of P6.pp P6.ppa   WBbt:0006991
cell, posterior daughter of P6.pa P6.pap   WBbt:0006990
cell, anterior daughter of P6.pa P6.paa   WBbt:0006989
post-embryonic cell of pedigree P5.ppa P5.ppa   WBbt:0007256
post-embryonic cell of pedigree P5.pp P5.pp   WBbt:0007255
post-embryonic cell of pedigree P5.pap P5.pap   WBbt:0007254
post-embryonic cell of pedigree P5.paa P5.paa   WBbt:0007253
post-embryonic cell of pedigree P7.ppp P7.ppp   WBbt:0007266
post-embryonic cell of pedigree P7.ppa P7.ppa   WBbt:0007265
post-embryonic cell of pedigree P7.pap P7.pap   WBbt:0007264
post-embryonic cell of pedigree P6.ppp P6.ppp   WBbt:0007260
Anterior daughter cell of P8.p, fuses into postembryonic large hypodermal syncytium in hermaphrodite. P8.pa lineage name: P8.pa WBbt:0004147
Posterior daughter cell of P8.p, fuses into postembryonic large hypodermal syncytium in hermaphrodite. P8.pp lineage name: P8.pp WBbt:0004145
Anterior daughter cell of P3.p, fuses into postembryonic large hypodermal syncytium in hermaphrodite. P3.pa lineage name: P3.pa WBbt:0004155
Posterior daughter cell of P3.p, fuses into postembryonic large hypodermal syncytium in hermaphrodite. P3.pp lineage name: P3.pp WBbt:0004153
Anterior daughter cell of P4.p, fuses into postembryonic large hypodermal syncytium in hermaphrodite. P4.pa lineage name: P4.pa WBbt:0004151

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00001186 egl-18 F55A8.1 Caenorhabditis elegans

3 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch. L3 larva Ce WBls:0000035
  The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch. L2 larva Ce WBls:0000027
  The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch. L4 larva Ce WBls:0000038