WormMine: AnatomyTerm WBbt:0004888

• Definition: Male specific interneuron, project into preanal ganglion
• Name: CP8
• Primary Identifier: WBbt:0004888
• Synonym: lineage name: P10.aapp

1 Children

Definition	Name	Synonym	Primary Identifier
nucleus of pedigree P10.aapp	P10.aapp nucleus		WBbt:0001907

0 Expression Clusters

6 Expression Patterns

• Primary Identifier: Expr15433

• Primary Identifier: Expr11002
• Pattern: pdf-1 was expressed in both sexes in the head interneurons SAAV, SAAD, SIAV, AVB, AIM, RMG and two other unidentified ciliated neurons (possibly ASK and AFD). In the tail, pdf-1 was consistently expressed in interneurons PVN, LUA, PVT, and the pair PVS and PVU (referred to as PVP left and right in the hermaphrodite). Expression was also observed in male­-specific neurons (ventral cord neurons CP7 and CP8, and PDC) and in one unidentified interneuron, possibly PVX, in the pre­-anal ganglion.

• Primary Identifier: Expr12670
• Pattern: egl-8 is expressed in the vas deferens, spicule protractor muscles, diagonal muscles and a male-specific neuron that is probably CP8 or CP9 and is also widely expressed in the nervous system, as expected from previous work (Lackner et al., 1999; Miller et al., 1999).

• Primary Identifier: Expr3702
• Pattern: Expression in male-specific structures is directed by all three promoters. Promoter pA directs expression in the spicule protractor muscles of the proctodeum and in a single male-specific neuron that is likely to be CP8 or CP9. Promoter pB directs expression in the spicule retractor muscles, gubernaculum retractor muscles, posterior oblique muscles, diagonal muscles, and the vas deferens. Promoter pC also directs expression in the vas deferens, as well as the seminal vesicle and the valve that separates the seminal vesicle and vas deferens. Thus itr-1 is expressed widely in the sex-associated muscles and somatic gonad of males.

• Primary Identifier: Expr13235
• Pattern: In both males and hermaphrodites, bnc-1 is almost exclusively expressed in VA and VB motorneurons. Weaker expression is also observed in the SABV neuron pair. The protein localizes exclusively to nuclei. bnc-1 expression is initiated around the postembryonic birth of VA and VB MNs at the late first larval (L1) stage and is maintained throughout the life of the animals. A similar expression pattern is observed with successively smaller reporter gene constructs: (1) a fosmid reporter in which bnc-1 is tagged at the C terminus, (2) the aforementioned rescue construct that contains sequences 1.8 kb upstream of the start codon all the way to the stop codon, or (3) a promoter fusion construct that only contains the sequence 1.8 kb upstream of the start codon. Besides VA/VB MNs, bnc-1 is also expressed in the male-specific CP7 MN and CP8 interneuron in the VNC.
• Subcellular Localization: The protein localizes exclusively to nuclei.

• Primary Identifier: Expr13479
• Pattern: Onset of expression: VA1-VA12, VB2- VB11, SABVL/R: late L1.

0 Life Stages

2 Parents

Definition	Name	Synonym	Primary Identifier
Neuron class of nine male-specific neurons with cell body in ventral cord and preanal ganglion	CP neuron		WBbt:0005310
post-embryonic cell of pedigree P10.aap in male.	P10.aap male		WBbt:0008099