1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00015478 | mapk-15 | C05D10.2 | Caenorhabditis elegans |
| Primary Identifier | Expr13559 | Subcellular Localization | A functional MAPK-15c fusion protein localizes at the ciliary base and along the axonemes of most or all ciliated neurons. An identical localization pattern is also found for worms with a mapk-15a::gfp transgene expressed at low levels. In cilia, MAPK-15c appears to localize preferentially to the middle segments in examined neurons. At the ciliary base, MAPK-15 is largely excluded from the transition zone marked with TMEM- 107 and NPHP-4, but colocalizes with the basal body marker GASR-8. In addition to accumulating at the basal body and axoneme, we observed a prominent pool of MAPK-15 1-2 μm proximal to the basal body, and in some images, the two pools appear to be connected by a strip of MAPK-15 signal. Based on its position, the proximal pool coincides with the proximal side of the periciliary membrane compartment (PCMC) where cell junctions (variably referred to as tight, belt, or apical junctions) connect the neuronal dendrites with a supporting sheath cell. In summary, MAPK-15 localizes to the ciliary axoneme middle segment, basal body, and apical junctions in sensory neurons. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00015478 | mapk-15 | C05D10.2 | Caenorhabditis elegans |
