WormMine: ExpressionPattern Expr1036

• Pattern: APH-2 protein is first detected during oogenesis. APH-2 is associated with the plasma membranes that partially surround the developing oocyte nuclei and with the surface membranes of mature oocytes. In newly fertilized eggs and in early cleavage stage embryos, APH-2 is associated with the peripheral membranes of all blastomeres. The APH-2 protein can be detected on, or near, plasma membranes throughout the first 5-6 hours of embryogenesis. The APH-2 protein that is observed after the 28-cell stage may represent protein that persists from maternal expression of aph-2, or may result from de novo embryonic expression. aph-2 mutant embryos analyzed in this study lack both maternal and embryonic aph-2(+) activity, and fail to show any detectable APH-2 protein. Embryonically expressed APH-2 protein was not detected in early embryos that were obtained from aph-2 mutant hermaphrodites mated with aph-2(+) males.
• Primary Identifier: Expr1036
• Subcellular Localization: plasma membranes

1 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
a female haploid germ cell.	oocyte	ovum	WBbt:0006797

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00000148	aph-2	ZC434.6	Caenorhabditis elegans

2 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003
	The stage after an hermaphrodite animal is fully-developed and reaches maturity.		adult hermaphrodite Ce	WBls:0000057