WormMine: ExpressionPattern Expr2672

• Pattern: CLK-1 protein is clearly detectable in maternally rescued animals at all four larval stages. The amount of CLK-1, however, is considerably lower than in wild-type animals. Moreover, in the wild type, the amount of CLK-1 per animal increases during development, indicating that CLK-1 is actively synthesized. In contrast, the total amount of CLK-1 in maternally rescued animals appears constant, indicating that there is little degradation of CLK-1 during larval development, despite the very active larval growth.
• Primary Identifier: Expr2672
• Remark: Although no clk-1 mRNA can be detected in maternally rescued mutants, it remains possible that CLK-1 is produced in maternally rescued animals because of the presence of undetectable levels of a maternally derived transcript. However, none of the CLK-1 protein detected in maternally rescued clk-1 mutants could be produced from the zygotic genome, as the qm30 mutation is a partial deletion of the gene that would result in a truncated protein, and as no CLK-1 protein at all is detected in clk-1(qm30) mutants. In conclusion, the presence of maternally derived wild-type CLK-1 protein in clk-1 maternally rescued animals likely accounts for the maternal rescue.

0 Anatomy Terms

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00000536	clk-1	ZC395.2	Caenorhabditis elegans

4 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch.		L3 larva Ce	WBls:0000035
	The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.		L2 larva Ce	WBls:0000027
	The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch.		L4 larva Ce	WBls:0000038
	The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.		L1 larva Ce	WBls:0000024