| Primary Identifier | Expr16492 | Subcellular Localization | To assess the intracellular localization of LGC-41, we generated a single-copy functional green fluorescence protein (GFP)-tagged LGC-41, integrated at the chromosomal locus by CRISPR insertion, which when expressed in Xenopus oocytes appeared to form a functional channel with a comparable betaine EC50 to the wild-type channel. We observed localization of LGC-41::GFP in clear punctate structures in the synaptically dense nerve ring region as well as more diffuse staining including in the vicinity of sensory nerve endings in the nose. This localization suggests a possible neuronal function for LGC-41 and its ligand, betaine, in neuronal communication or chemosensation. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| the most extensive region of neuropil in the animal, consists of a large toroidal bundle of processes. | nerve ring | circumpharyngeal nerve ring | WBbt:0006749 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00008022 | lgc-41 | C39B10.2 | Caenorhabditis elegans |
