1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00003150 | mbk-2 | F49E11.1 | Caenorhabditis elegans |
| Primary Identifier | Expr3804 | Subcellular Localization | GFP:MBK-2 relocalizes abruptly from the cortex to cortical puncta in anaphase/telophase of meiosis I and progressively from cortical puncta to the cytoplasm during meiosis II and meiotic exit. Consistent with two distinct steps of relocalization, embryos arrested before or during metaphase I maintain GFP:MBK-2 uniformly at the cortex, whereas embryos arrested in metaphase II maintain GFP:MBK-2 in cortical puncta, with some puncta in the cytoplasm (20/24 zyg-11(RNAi) gonads). In spe-9 eggs, GFP:MBK-2 progressed from the cortex into cortical puncta and the cytoplasm as in wild-type embryos, suggesting that meiotic exit, rather than meiosis II, is critical. In wee-1.3(RNAi) oocytes, relocalization of GFP:MBK-2 to cortical puncta and to the cytoplasm occurred precociously in oocytes . This premature relocalization was blocked by CDK-1 and MAT-1 depletion. Authors concluded that GFP:MBK-2 relocalizes from the cortex to the cytoplasm in a two-step process linked to progression past metaphase I and possibly to meiotic exit. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00003150 | mbk-2 | F49E11.1 | Caenorhabditis elegans |
