1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00002232 | kpc-1 | F11A6.1 | Caenorhabditis elegans |
| Pattern | We found that a functional KPC-1:: sfGFP reporter specifically expressed in PVD localized to higher-order dendritic branches of PVD neurons as well as to the PVD axonal compartment. We further found that the putative transmembrane domain of KPC-1 was necessary to direct PVD dendritic patterning because a construct lacking the predicted C-terminal transmembrane domain (S675 to S688) failed to rescue the kpc-1 mutant phenotype, whereas a construct containing a heterologous transmembrane domain of PAT-3/ β-integrin (PAT-3-TM) rescued the defects. We conclude that, in vivo, KPC-1 is localized to a membrane compartment in higher-order dendrite branches and is therefore potentially in proximity to both MNR-1 expressed by epidermal cells and the DMA-1 receptor in PVD. | Primary Identifier | Expr16429 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00002232 | kpc-1 | F11A6.1 | Caenorhabditis elegans |
