1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00004887 | smn-1 | C41G7.1 | Caenorhabditis elegans |
| Primary Identifier | Expr13407 | Subcellular Localization | SMN-1 expressed from the rescuing smn-1::mCherry transgene is seen in the nucleus and cytoplasm. In the cytoplasm, most SMN-1::mCherry is found at myofilaments in regularly spaced puncta. These puncta appear more ordered in adult muscle as compared with younger muscle. The SMN-1 expression pattern at muscle myofilaments resembles that of ARX-2::mCherry. To test whether ARX-2 and SMN-1 colocalize, we generated transgenic animals expressing both smn-1::GFP and arx-2::mCherry in muscle. SMN-1::GFP colocalizes with ARX-2::mCherry at the thin filaments. However, only SMN-1 is observed in the nucleus. We occasionally observed SMN-1::GFP and ARX-2::mCherry in peri-nuclear puncta. We conclude that SMN-1 and ARX-2 colocalize at muscle myofilaments adjacent to elongated mitochondrial tubules. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00004887 | smn-1 | C41G7.1 | Caenorhabditis elegans |
