WormMine: AnatomyTerm WBbt:0005661

• Definition: Neuron class of two neurons that have dual ciliated endings in the amphid sensillum; the endings are in the amphid channel, which is open to the outside.
• Name: ADL
• Primary Identifier: WBbt:0005661

2 Children

Definition	Name	Synonym	Primary Identifier
Amphid neuron, prob. chemosensory	ADLL	lineage name: ABalppppaad	WBbt:0003997
Amphid neuron, prob. chemosensory	ADLR	lineage name: ABpraaapaad	WBbt:0003995

9 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
postdauer (pheromone)	Transcripts that showed significantly increased expression in ADL neurons FACS-isolated from postdauer (pheromone) one-day old adults of nrde-3(gg66) animals, comparing to ADL nuerons isolated from control nrde-3(gg66) animals.	Data analysis was performed on the CLC Genomics Workbench (Qiagen) with differential expression assessed using EdgeR.	WBPaper00067348:Post-dauer_upregulated_nrde-3(gg66)_ADL
	Transcripts that showed significantly decreased expression in ADL neurons of qui-1(db104) comparing to in N2 at day 1 adult stage.	tximport 1.14.2 and DEseq2 1.26.0. Fold change > 2, FDR < 0.05.	WBPaper00062520:qui-1(db104)_downregulated
postdauer (pheromone)	Transcripts that showed significantly decreased expression in ADL neurons FACS-isolated from postdauer (pheromone) one-day old adults of N2 animals, comparing to ADL nuerons isolated from control N2 animals.	Data analysis was performed on the CLC Genomics Workbench (Qiagen) with differential expression assessed using EdgeR.	WBPaper00067348:Post-dauer_downregulated_N2_ADL
	Top 300 transcripts enriched in ADF, ADL, AFD, ASE, ASG, ASH, ASI, ASJ, ASK, AWA, AWB, AWC according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:Ciliated_amphid_neuron
postdauer (pheromone)	Transcripts that showed significantly increased expression in ADL neurons FACS-isolated from postdauer (pheromone) one-day old adults of N2 animals, comparing to ADL nuerons isolated from control N2 animals.	Data analysis was performed on the CLC Genomics Workbench (Qiagen) with differential expression assessed using EdgeR.	WBPaper00067348:Post-dauer_upregulated_N2_ADL
	Transcripts that showed significantly increased expression in ADL neurons of qui-1(db104) comparing to in N2 at day 1 adult stage.	tximport 1.14.2 and DEseq2 1.26.0. Fold change > 2, FDR < 0.05.	WBPaper00062520:qui-1(db104)_upregulated
	Single-cell RNA-Seq cell group 91 expressed in: ADL.	CellRanger, DecontX, Monocle3, Louvain algorithm.	WBPaper00065623:91
postdauer (pheromone)	Transcripts that showed significantly decreased expression in ADL neurons FACS-isolated from postdauer (pheromone) one-day old adults of nrde-3(gg66) animals, comparing to ADL nuerons isolated from control nrde-3(gg66) animals.	Data analysis was performed on the CLC Genomics Workbench (Qiagen) with differential expression assessed using EdgeR.	WBPaper00067348:Post-dauer_downregulated_nrde-3(gg66)_ADL
	Transcripts enriched in ADL according to single cell RNAseq.	Genes that pass the Bonferroni threshold for multiple comparisons (q < 0.05) are significantly enriched.	WBPaper00061651:ADL_enriched

0 Expression Patterns

0 Life Stages

2 Parents

Definition	Name	Synonym	Primary Identifier
neuron of the amphid sensillum	amphid neuron	amphid sensory neuron	WBbt:0005394
neuron that senses soluable chemicals	chemosensory neuron		WBbt:0005837