WormMine

WS294

Intermine data mining platform for C. elegans and related nematodes

Anatomy Term :

Definition  Neuron class of eleven motoneurons, distributed along the ventral cord, which innervate ventral body muscles. Name  VB neuron
Primary Identifier  WBbt:0005336

11 Children

Definition Name Synonym Primary Identifier
Ventral cord motor neuron, innervates ventral body muscles VB9 lineage name: P8.aaap WBbt:0004627
Ventral cord motor neuron, innervates ventral body muscles VB10 lineage name: P9.aaap WBbt:0004625
Ventral cord motor neuron, innervates ventral body muscles VB11 lineage name: P10.aaap WBbt:0004623
Ventral cord motor neuron, innervates ventral body muscles VB5 lineage name: P4.aaap WBbt:0004637
Ventral cord motor neuron, innervates ventral body muscles VB6 lineage name: P5.aaap WBbt:0004633
Ventral cord motor neuron, innervates ventral body muscles VB7 lineage name: P6.aaap WBbt:0004631
Ventral cord motor neuron, innervates ventral body muscles VB8 lineage name: P7.aaap WBbt:0004629
Ventral cord motor neuron, innervates ventral body muscles, also interneuron in ring VB1 lineage name: P1.aaap WBbt:0004643
Ventral cord motor neuron, innervates ventral body muscles VB2 lineage name: W.aap WBbt:0004641
Ventral cord motor neuron, innervates ventral body muscles VB3 lineage name: P2.aaap WBbt:0004639
Ventral cord motor neuron, innervates ventral body muscles VB4 lineage name: P3.aaap WBbt:0004638

138 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  Single-cell RNA-Seq cell group 34 expressed in: Seam cells (grd+). CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:34
  Single-cell RNA-Seq cell group 74 expressed in: Vulval cells. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:74
  Single-cell RNA-Seq cell group 52 expressed in: Spermatheca neck distal-most. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:52
  Single-cell RNA-Seq cell group 37 expressed in: e1_e3 (pharyngeal epithelium). CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:37
  Single-cell RNA-Seq cell group 62 expressed in: e2 (pharyngeal epithelium). CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:62
  Single-cell RNA-Seq cell group 76 expressed in: pm1_pm2 (pharyngeal muscle). CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:76
  Single-cell RNA-Seq cell group 157 expressed in: M1. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:157
  Single-cell RNA-Seq cell group 96 expressed in: AIN. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:96
  Single-cell RNA-Seq cell group 36 expressed in: Spermatheca bag proximal. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:36
  Single-cell RNA-Seq cell group 164 expressed in: g1A (pharyngeal gland) . CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:164
  Single-cell RNA-Seq cell group 111 expressed in: AWC. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:111
  Single-cell RNA-Seq cell group 104 expressed in: AWA. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:104
  Single-cell RNA-Seq cell group 105 expressed in: AWB. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:105
  Single-cell RNA-Seq cell group 91 expressed in: ADL. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:91
  Single-cell RNA-Seq cell group 125 expressed in: AFD. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:125
  Single-cell RNA-Seq cell group 148 expressed in: ADF. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:148
  Single-cell RNA-Seq cell group 106 expressed in: ASH. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:106
  Single-cell RNA-Seq cell group 114 expressed in: ASI. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:114
  Single-cell RNA-Seq cell group 121 expressed in: ASE. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:121
  Single-cell RNA-Seq cell group 126 expressed in: ASG. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:126
  Single-cell RNA-Seq cell group 117 expressed in: ASJ. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:117
  Single-cell RNA-Seq cell group 110 expressed in: ASK. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:110
  Single-cell RNA-Seq cell group 35 expressed in: Mature sperm. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:35
  Single-cell RNA-Seq cell group 40 expressed in: Arcade cells and rectal gland subpopulation. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:40
  Single-cell RNA-Seq cell group 55 expressed in: Intestinal-rectal valve. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:55
  Single-cell RNA-Seq cell group 51 expressed in: Intestine anterior. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:51
  Single-cell RNA-Seq cell group 65 expressed in: Excretory gland. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:65
  Single-cell RNA-Seq cell group 151 expressed in: Cephalic and inner labial socket. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:151
  Single-cell RNA-Seq cell group 44 expressed in: Glia_1. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:44
  Single-cell RNA-Seq cell group 93 expressed in: Glia_2. CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:93

66 Expression Patterns

Remark Reporter Gene Primary Identifier Pattern Subcellular Localization
    Expr4864 A-class motor neuron: enriched in embryo (2.0) and larva (2.1). Neuronal expression include: DA, DB, VA, VB, DD, VD, head neurons. Also expressed in other cells: Pharyngeal muscle. Pan-neuronal: enriched in embryo (1.7) and larva (3.5).  
    Expr4865 A-class motor neuron: enriched in embryo (1.8) and larva (1.8). Neuronal expression include: DA, DB, DD, VA, VB, VD, AS, head neurons. Also expressed in other cells: Head muscle. Pan-neuronal: enriched in embryo (1.8) and larva (1.5).  
    Expr4866 A-class motor neuron: enriched in embryo (2.1) and larva (1.9). Neuronal expression include: DA, DB, VA, VB. Pan-neuronal: enriched in embryo (1.9) and larva (2.2).  
    Expr4867 A-class motor neuron: enriched in embryo (5.3) and larva (3.7). Neuronal expression include: DA, DB, VA, VB, AS, head neurons. Also expressed in other cells: Body muscle, intestine. Pan-neuronal: enriched in embryo (3.9) and larva (8.3).  
    Expr4868 A-class motor neuron: enriched in embryo (5.1) and larva (1.7). Neuronal expression include: DA, DB, VA, VB, VD. Also expressed in other cells: Intestine, hypodermis. Pan-neuronal: enriched in embryo (1.9) and larva (2.7).  
    Expr4869 A-class motor neuron: enriched in embryo (3.6) and larva (3.1). Neuronal expression include: DA, DB, VA, VB, VC, touch neurons, head and tail neurons. Pan-neuronal: enriched in embryo (2.3) and larva (4.0).  
    Expr4860 A-class motor neuron: enriched in embryo (4.0) and larva (2.2). Neuronal expression include: DA, DB, VA, VB, head and tail neurons. Pan-neuronal: expressed in embryo; enriched in larva (2.3).  
    Expr4862 A-class motor neuron: enriched in embryo (1.9) and larva (2.1). Neuronal expression include: DA, VB, DB, VD, DD, bright in AS, also head and tail neurons. Pan-neuronal: expressed in embryo; enriched in larva (3.5).  
    Expr4854 A-class motor neuron: expressed in embryo; enriched in larva (1.6). Neuronal expression include: Posterior ventral cord motor neurons (VA, VB, DB, AS), head and tail neurons, touch neurons. Pan-neuronal: expressed in embryo; enriched in larva (3.0).  
    Expr4856 A-class motor neuron: expressed in embryo; enriched in larva (1.9). Neuronal expression include: L2 -- DA, VA, VB, VD, bright in touch neurons, head and tail neurons L3 -- all ventral cord motor neurons. Pan-neuronal: expressed in embryo; enriched in larva (5.9).  
    Expr4858 A-class motor neuron: enriched in embryo (2.8) and larva (3.1). Neuronal expression include: DA, VB, AS, DB, DD, HSN, VC4&5, AIY, head neurons. Also expressed in other cells: Muscle, intestine. Pan-neuronal: expressed in embryo; enriched in larva (1.5).  
    Expr4851 A-class motor neuron: enriched in embryo (1.7); not expressed in larva. Neuronal expression include: DA, VD, AS, VB, DB. Also expressed in other cells: Body muscle. Pan-neuronal: expressed in embryo; enriched in larva (2.7).  
    Expr4845 A-class motor neuron: expressed in larva; enriched in embryo (2,5). Neuronal expression include: DA, DB, DD, VA, VB, VD, AS head and tail neurons. Also expressed in other cells: Body muscle, head muscle, pharyngeal muscle. Pan-neuronal: enriched in embryo (2.1) and larva (1.8).  
    Expr4846 A-class motor neuron: not expressed in embryo or larva. Neuronal expression include: All VNC motor neuron classes, except DD, head and tail neurons. Pan-neuronal: enriched in larva (4.9); not expressed in embryo.  
    Expr4848 A-class motor neuron: expressed in larva; enriched in embryo (1.8). Neuronal expression include: VA, VB, DA, DB, AS, touch neurons. Also expressed in other cells: Body muscle, pharyngeal neurons. Pan-neuronal: enriched in larva (1.8); not expressed in embryo.  
Picture: Fig. 3A, B, C, D.   Expr4902 In the transgenic animals carrying crm-1a::gfp reporter, consistent signals were detected in neurons in the ventral nerve cord. By the positions and clustering of the cell body as well as the axonal outgrowth along the ventral nerve cord, crm-1a is found to be expressed in the DA neurons 2 to 7, the DB neurons 3 to 7 and additional neurons in the VA, VB and AS classes along the nerve cord (VNC). Expression was also observed in neurons around the pharynx. In the male tail, gfp signals in the RnA neuronal cells of sensory rays 2 and 4 and the PVR neuron with the entire axonal process along the VNC were also observed. Entire axonal process of PVR along the VNC.
    Expr13411 The Venus reporter driven by the 5.7 kb npr22 promoter was expressed in many cells mainly in the head region; the npr-22prom::Venus expression was observed in head muscles, the I2 neurons, the MC neurons, the RIH neuron, the AIA neurons, the AUA neurons, the ASK neurons (strong in larval worms), the ASI neurons (strong in larval worms), a few B-type motorneurons in the posterior ventral nerve cord (variable), pharyngeal muscles, body wall muscles (weak), the intestine (weak), and a few classes of unidentified cells anterior to the nerve ring. In the I2, MC, RIH, AIA, AUA, and posterior B-type motorneurons, we confirmed the co-expression of established cell markers.  
    Expr13164 For lgc-38, all expressing cells shown are observed with the 3.5 kb reporter fusion, except for OLL, which only expresses the 3.9 kb fusion; URA expresses both.  
Picture: Fig 3.   Expr8850 Neuronal Expression: AVA, AVB, AVE, PVC, AIB, AUA, AVG, RIB, RIC, SAA, SIA, SIB, RIF, RIM, RMD, RME, SMD, DA, DB, VA, VB, M5, NSM, MC, I3, MI?. Non-neuronal Expression: rectal epithelium, body wall muscle, spermethecae, vulva muscle.  
    Expr12085 plr-1::GFP expression became visible in late gastrulation stage embryos. Strongest expression was detected in many cells in the tail region and by comma stage the most prominent expression was seen in body wall muscle cells. In early larval stages expression was detectable in a number of different tissues including the major hypodermal cells, muscle and marginal cells of the pharynx, the intestine (strongest in the anteriormost and posteriormost cells) as well as the anal depressor and stomatointestinal muscle. In the nervous system GFP expression was visible in a few neurons in head ganglia, many ventral cord motor neurons and several neurons in the tail ganglia including the PDA neuron. Based on the lack of commissures the motor neurons are likely of the VA, VB, VC and/or AS class. Based on the number of cells the majority (or even all) of these classes express GFP. In general expression was strongest in the tail region throughout development. This also held true for the motor neurons in the ventral cord, where GFP was strongest in the posterior-most cells and barely detectable in anterior motor neurons. Expression is maintained throughout larval development. In later larval stages expression is also seen occasionally in the distal tip cell of the developing gonad, the vulva and uterine muscle cells and the VC4 and VC5 neurons flanking the vulva. Expression in AVG, HSN or CAN neurons was not detectable with this reporter construct, but was detected in a previous study in HSN and CAN using a longer genomic construct (Moffat et al., 2014, Expr11480).  
    Expr8203 Expressed in DA, VB, AS, DB, DD, HSN, VC4 & 5, AIY, head neurons, muscles, intestine. acr-14::GFP is expressed in RME in the head and in ventral nerve cord (VNC) motor neurons.  
    Expr10808 ACR-2::GFP showed mostly diffused localization on neuronal soma, as well as processes in the ventral cord, sublateral cords, and nerve ring. In the ventral cord, expression of ACR-2::GFP was specifically observed in the VA, VB, DA, and DB motor neurons as reported previously (Jospin et al., 2009). Several additional cells (e.g., SDQ, vulva muscles) also expressed ACR-2::GFP, presumably because of the use of a longer promoter and inclusion of intronic sequences. However, staining of ACR-2::GFP was not seen in the dorsal nerve cord. Because the axonal processes of DA and DB motor neurons are major constituents of the dorsal nerve cord, lack of ACR-2::GFP signals in the dorsal nerve cord indicates that ACR-2 is unlikely to localize to presynaptic sites of these motor neurons.  
    Expr3136 C33G8.5 showed medium to strong expression in scattered nonchemosensory neurons.5  
    Expr13958 egl-44 expression was much more restricted then zag-1, being found only in the FLP, ADL, and SAB neurons, as well as a few VA and VB motor neurons. Moreover, egl-44 was widely expressed in hypodermis, pharynx, and intestine, whereas zag-1 expression was absent in these tissues.  
Picture: Figure 8. Reporter gene fusion type not specified.   Expr7974 Expressed in head and tail neurons, VA, VBs. Also expressed in head muscle, intestine.  
Picture: Figure 8. Reporter gene fusion type not specified.   Expr7965 Expressed in AS, VD, VB, VA, head and tail neurons. Also expressed in intestine, head muscle, gonadal sheath cell.  
Picture: Fig 3.   Expr8671 Expression in the alimentary canal: Strong and consistent expression in pharyngeal epithelium, pm5, pm6, pm7, pm8, g2, rectal gland cells. Weak or rare expression in anterior arcades, posterior arcades, pm2, pm3, pm4, M3, MC, intestine, rectal epithelial cells. Expression in the nervous system: CEPsh, ALN, ASn, CAN, DAn, DBn, DDn, DVA, DVB, HSN, PDE, PLM, PVQ, PVR, PVT, URB, VAn, VBn, VDn, M3, MC. Expression in the reproductive system: In adult stage, expressed in spermatheca, vulval muscle, HSN. In developing larva stage, expressed in vulval muscle, uterine muscle, HSN. inx-3 was expressed broadly during early embryogenesis. After the beginning of morphogenesis, inx-3 expression becomes more restricted to the pharynx, hypodermis, and intestine. By three-fold stage inx-3 expression appears in ventral cord motor neurons (strongest in DA neurons) along with continued strong pharyngeal expression. By hatching, its hypodermal expression disappears, while postembryonically born ventral cord motor neurons express it at low levels. Its pharyngeal (strong) and neuronal (faint) expressions continue to adulthood.  
Neuronal gene expression pattern from collation by Shawn Lockery of neuron-specific promotors posted 20/04/98 (http://chinook.uoregon.edu). Since cell AS is listed under 'body' in the pattern, it presumably means the AS.1-11 ventral cord neurons rather than the AS amphid neurons.[sdm-curator]   Expr320 head: IL2 URA URB SAA SAB SIA SIB SMB SMD RMD AIY, sev more; phar: M1 M2 M5 I1f I6f, others; body: VA VB VC DA DB AS SDQ HSNf; tail: ALN PLN others [J. Duerr (personal communication to Shawn Lockery)], antibody  
Picture: Fig 3.   Expr8694 Expression in the alimentary canal: Strong and consistent expression in M5, I1, I3, I6, NSM. Weak or rare expression in posterior arcades. Expression in the nervous system: Phsh, ADA, ADE, ADL, AIN, AIY, ALM, AUA, AVA, AVD, AVH, AVJ, AVK, AVM, AWB, BDU, CAN, CEP, DAn, DBn, DDn, DVB, DVC, FLP, HSN, IL1, IL2, LUA, OLL, PDA, PDB, PDE, PHA, PHB, PHC, PLM, PLN, PVC, PVD, PVM, PVN, PVP, PVQ, PVR, PVT, PVW, RIB, RIC, RIF, RIP, RIS, RME, SDQ, SIA (early larva), SIB (early larva), SMB (early larva), SMD (early larva), URA, URB, VAn, VBn, VCn, VDn, M5, I1, I6, NSM. Expression in the reproductive system: In adult stage, expressed in vulval muscle, uterine muscle, HSN, VCn. In developing larva stage, expressed in HSN, VCn, and anchor cell.  
    Expr13161    

0 Life Stages

2 Parents

Definition Name Synonym Primary Identifier
neuron making synapse on an effector (muscle, gland). motor neuron motoneuron WBbt:0005409
neuron that uses vesicular acetylcholine as a neurotransmitter. cholinergic neuron ACh neuron WBbt:0006840