WormMine: AnatomyTerm WBbt:0006837

• Definition: neuron that uses serotonin as a vesicular neurotransmitter.
• Name: serotonergic neuron
• Primary Identifier: WBbt:0006837
• Synonym: 5-HT neuron

17 Children

Definition	Name	Synonym	Primary Identifier
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC4	lineage name: P6.aap	WBbt:0004617
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC5	lineage name: P7.aap	WBbt:0004613
Male specific neuron, innervates dorsal muscles	CA4	lineage name: P6.aapa	WBbt:0003806
Male specific cell, not reconstructed	CA2	lineage name: P4.aapa	WBbt:0003808
Male specific cell, not reconstructed	CA3	lineage name: P5.aapa	WBbt:0003807
Male specific cell, not reconstructed	CA1	lineage name: P3.aapa	WBbt:0003809
Neuron class of one ring interneuron.	RIH	lineage name: ABprpappaaa	WBbt:0003928
Male specific motor neuron in ventral cord	CP6	lineage name: P8.aapp	WBbt:0004891
Male specific motor neuron in ventral cord	CP4	lineage name: P6.aapp	WBbt:0004895
Male specific motor neuron in ventral cord	CP5	lineage name: P7.aapp	WBbt:0004893
Male specific cell in ventral cord, not reconstructed	CP2	lineage name: P4.aapp	WBbt:0004899
Male specific cell in ventral cord, not reconstructed	CP3	lineage name: P5.aapp	WBbt:0004897
Male specific cell in ventral cord, not reconstructed	CP1	lineage name: P3.aapp	WBbt:0004901
Neuron class of two interneurons with cell bodies in the ventral ganglion behind the excretory duct.	AIM		WBbt:0006814
Neuron class of two motoneurons that innervate vulval muscles in the hermaphrodite.	HSN	hermaphrodite specific neuron	WBbt:0006830
Neuron class of two neurons that have dual ciliated endings in the amphid sensillum. The endings are in the amphid channel, which is open to the outside. Processes from lateral cell bodies enter the ventral cord via the amphidial commissures and turn anteriorly to enter the nerve ring. The processes of ADF run near the outside surface and posterior face of the ring, in close association with those of AIZ. They meet at the dorsal mid-line and terminate; there is a gap junction at the point or contact. The main synaptic output is to RIA and AIZ; there are also synapses to SMB, AUA and RIR, usually in dyadic combinations with RIA or AIZ. AWB synapses onto ADF in several places, and there are gap junctions to RIH, ADA and AIA.	ADF		WBbt:0005660
Neuron class of two pharyngeal neurosecretory-motor neurons.	NSM	neurosecretory-motor neuron	WBbt:0003666

0 Expression Clusters

7 Expression Patterns

• Primary Identifier: Expr4817
• Remark: Picture: Fig. 2G.
• Pattern: In wild-type animals, GFP was observed in all identified serotonergic and dopaminergic neurons and many muscle cells. Please note: this strain -JY739- shows expression in biogenic amine neurons and the epidermis, not in muscle cells (Loer et al., 2015. Genetics. WBPaper00046585, Expr12165).

• Primary Identifier: Expr12168
• Pattern: qdpr-1 was expressed in the epidermis -similar to what observed in cat-4 transgenics- but was not highly expressed in 5HT and DA neurons. These transgenics all also showed some expression of varying intensity in other cells (non-epidermal cells, and non-5HT and non-DA neurons in the head and body). A qdpr-1 full-length translational fusion was expressed in several known 5HT and DA neurons, including NSMs, ADFs, CEPs, and other cells.

• Primary Identifier: Expr12165
• Pattern: GFP reporter constructs show cat-4 expression in identified serotonergic and dopaminergic neurons (where tryptophan hydroxylase and tyrosine hydroxylase are expressed, respectively), and in the epidermis (where both phenylalanine hydroxylase and alkylglycerol monooxygenase are expressed). Overall, in larval and adult worms, strong expression was observed in serotonergic and dopaminergic neurons, in most of the epidermis - especially the large epidermal syncytium (hyp7) - and more weakly in some intestinal cells. NSM and CEP neuron somas are seen in the head, plus some neuronal processes (especially CEP processes). A few other neuronal somas stain less brightly. The anterior intestine also shows GFP expression, as do some rectal epithelial cells (likely B & Y cells). The cat-4 reporter constructs examined were coming from three different sources, including some previously described by others (Sze et al. 2002, Flames and Hobert 2009). The JY739 strain showed expression in biogenic amine neurons and the epidermis, not in muscle cells as reported (Sze et al. 2002). GFP reporter constructs show cat-4 expression in identified serotonergic and dopaminergic neurons (where tryptophan hydroxylase and tyrosine hydroxylase are expressed, respectively), and in the epidermis (where both phenylalanine hydroxylase and alkylglycerol monooxygenase are expressed). Overall, in larval and adult worms, strong expression was observed in serotonergic and dopaminergic neurons, in most of the epidermis - especially the large epidermal syncytium (hyp7) - and more weakly in some intestinal cells. NSM and CEP neuron somas are seen in the head, plus some neuronal processes (especially CEP processes). A few other neuronal somas stain less brightly. The anterior intestine also shows GFP expression, as do some rectal epithelial cells (likely B & Y cells).The cat-4 reporter constructs examined were coming from three different sources, including some previously described by others (Sze et al. 2002, Flames and Hobert 2009). The JY739 strain showed expression in biogenic amine neurons and the epidermis, not in muscle cells as reported.

• Primary Identifier: Expr12166
• Pattern: ptps-1::GFP transgenics with the shorter upstream sequence resembled the cat-4 expression pattern, with expression in some epidermal cells, and a few serotonergic neurons. The ptps-1 reporters, however, were also observed in additional cells (including anterior intestine, VC4, 5 (weak) and HSN, plus lateral seam cells), and were not expressed in other epidermal cells or in all 5HT and DA neurons, suggesting these reporters may lack important positive or negative regulatory elements.

• Primary Identifier: Expr9992
• Pattern: In wild-type, this functional cat-1 fusion to GFP was specifically expressed in all predicted serotonergic and dopaminergic neurons.

• Primary Identifier: Expr1200373
• Pattern: Data from the TransgeneOme project

• Primary Identifier: Expr11668
• Pattern: BAS-1::GFP was expressed in both serotonergic and dopaminergic neurons at a high level in young worms and a relatively low level in aged worms.

0 Life Stages

1 Parents

Definition	Name	Synonym	Primary Identifier
Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses.	neuron	neurone	WBbt:0003679