1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00000257 | bmk-1 | F23B12.8 | Caenorhabditis elegans |
| Primary Identifier | Expr4769 | Remark | As expected, immunostaining is absent in bmk-1(ok391) and bmk-1(RNAi) embryos at all stages of the cell cycle and development. |
| Subcellular Localization | The affinity-purified BMK-1 antibody was used to localize BMK-1 in the C. elegans germline and embryos. These experiments revealed that BMK-1 is expressed at high levels in the hermaphrodite germline and is ubiquitously associated with nuclei at every stage of oogenesis. After fertilization, BMK-1 is localized to the meiotic spindle and with the meiotic midbody. Like AIR-2, it also persists on extruded polar bodies. In embryos, BMK-1 localization is dynamic with respect to the cell cycle. In prophase cells, BMK-1 protein begins to be associated with mitotic spindle microtubules. At metaphase, BMK-1 is strongly concentrated on the inner face of the centrosomes and mitotic spindle kinetochore microtubules, but it is not associated with astral microtubules. In early anaphase, the protein remains associated with kinetochore microtubules and begins to populate the central spindle . By late anaphase, BMK-1 is no longer localized to the poleward side of the separating chromosomes, but it is readily detectable at the central spindle. At telophase, all BMK-1 staining is localized to the spindle mid-body. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00000257 | bmk-1 | F23B12.8 | Caenorhabditis elegans |
