WormMine: ExpressionPattern Expr4213

• Pattern: Both reporters are expressed at the time of vulval induction at equal levels in P5.p, P6.p, and P7.p. After the first round of cell divisions, the translational DEP-1::GFP reporter is down-regulated in the primary lineage, but expression persists in the secondary vulval cells until the L4 stage. DEP-1::GFP expression is lower in P6.p than in P5.p or P7.p descendants in 82% of L3 and in 95% of L4 larvae (n = 26 and n = 21, respectively). A similar reduction of the expression in the primary lineage is observed with the transcriptional reporter, although the down-regulation in the primary lineage only becomes apparent at the Pn.pxx stage. dep-1p::gfp expression is lower in P6.p than in P5.p or P7.p descendants in 80% of the L3 larvae (n = 78). In most cases (e.g., 17 out of 18 larvae at the Pn.px and Pn.pxx stages), DEP-1::GFP expression is low or absent in cells expressing high LET-23 EGFR levels and vice versa.
• Primary Identifier: Expr4213
• Remark: No GO_term assigned.
• Subcellular Localization: Most of the DEP-1::GFP fusion protein is localized in intracellular punctae that partially colocalize with intracellular LET-23 EGFR.

15 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
descendent cell of post-embryonic blast cell P5, posterior, in hermaphrodite.	P5.p hermaphrodite		WBbt:0008121
	P7.p hermaphrodite		WBbt:0008129
	P6.p hermaphrodite		WBbt:0008125
Posterior daughter cell of P5.pp, fuses into hermaphrodite vulD syncytium.	P5.ppp	lineage name: P5.ppp	WBbt:0004477
Anterior daughter cell of P7.pa, fuses into hermaphrodite vulD syncytium.	P7.paa	lineage name: P7.paa	WBbt:0004448
cell, posterior descendent of P7.p	P7.pp		WBbt:0006984
cell, anterior descendent of P7.p	P7.pa		WBbt:0006983
post-embryonic cell of pedigree P5.pp	P5.pp		WBbt:0007255
post-embryonic cell of pedigree P5.pap	P5.pap		WBbt:0007254
post-embryonic cell of pedigree P5.paa	P5.paa		WBbt:0007253
post-embryonic cell of pedigree P5.pa	P5.pa		WBbt:0007252
post-embryonic cell of pedigree P7.ppa	P7.ppa		WBbt:0007265
post-embryonic cell of pedigree P7.pap	P7.pap		WBbt:0007264
post-embryonic cell of pedigree P5.ppa	P5.ppa		WBbt:0007256
post-embryonic cell of pedigree P7.ppp	P7.ppp		WBbt:0007266

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00009717	dep-1	F44G4.8	Caenorhabditis elegans

0 Life Stages