WormMine: AnatomyTerm WBbt:0003927

• Definition: Neuron class of one sensory neuron, basal body; not part of a sensillum, projects into ring.
• Name: AQR
• Primary Identifier: WBbt:0003927
• Synonym: lineage name: QR.ap

1 Children

Definition	Name	Synonym	Primary Identifier
nucleus of pedigree QR.ap	QR.ap nucleus		WBbt:0001656

5 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly altered expression at URX, AQR, and PQR neurons in camt-1(ok515) animals comparing to in wild type AX1888-1 strain.	RNA-seq data were mapped using PRAGUI - a Python 3-based pipeline for RNA-seq data analysis.	WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
	Top 300 transcripts enriched in ADE, AQR, BAG, CEP, FLP, IL1 neuron, IL2 neuron, OLL, OLQ, PDE, PHA, PHB, PQR, PVR according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:Ciliated_non_amphid_neuron
	Transcripts enriched in AQR according to single cell RNAseq.	Genes that pass the Bonferroni threshold for multiple comparisons (q < 0.05) are significantly enriched.	WBPaper00061651:AQR_enriched
	Single-cell RNA-Seq cell group 39_2 expressed in neuron.	scVI 0.6.0	WBPaper00065841:39_2
	Single-cell RNA-Seq cell group 122 expressed in: URX_AQR_PQR.	CellRanger, DecontX, Monocle3, Louvain algorithm.	WBPaper00065623:122

87 Expression Patterns

• Primary Identifier: Expr4204
• Remark: A translational DYF-2::GFP fusion was found to be localized only in cilia of CSN, thus precluding a confirmation of the cellular expression pattern obtained with the transcriptional dyf-2::gfp fusion or any further cell identification.
• Pattern: dyf-2::gfp expression was observed in only a subset of the ciliated sensory neuron (CSN) class in the worm. GFP signal was observed in seven out of twelve neurons of the amphids, including ASH, ASI, ASJ, ASK, ADL (ciliated neurons that fill with the fluorescent dye DiI) plus two hitherto unidentified amphid neurons. In addition, GFP expression was observed in the phasmid CSN and in neurons identified as AQR and PQR (asymmetric CSN in the head and tail, respectively). No or only very occasional GFP signal was detected in other CSN anterior to the nerve ring in the head of the worm.

• Primary Identifier: Expr4201
• Pattern: This construct expressed GFP ubiquitously in early embryos. The expression became progressively more restricted in older embryos and young larvae, and was not observed in adults. In larvae, expression was observed in dividing cells: ventral nerve cord neuroblasts, vulval precursors, dividing hypodermal seam cells, and the Q neuroblasts and their descendants.

• Primary Identifier: Expr4540
• Pattern: Expressed in AQR, PQR, URXL/R.

• Primary Identifier: Expr11223
• Pattern: egl-13 started to be expressed after Q.a divisions and GFP fluorescence reached the maximum level in Q.ap upon differentiation. By contrast, the GFP signal was barely detected in the Q.p lineage, and the mCherry fluorescence in Q cells did not change during Q cell development. egl-13 was continuously expressed in A/PQR during larval development, indicating that EGL-13 can be involved in neuronal fate initiation and maintenance.

• Primary Identifier: Expr15558

• Primary Identifier: Expr15571

• Primary Identifier: Expr15572

• Primary Identifier: Expr15573

• Primary Identifier: Expr15579

• Primary Identifier: Expr2937
• Pattern: Both ahr-1:GFP reporters are expressed during embryonic and larval development. Expression is first detected in two cells 260 min after the first cleavage. By midembryogenesis (pre-comma stage), 14 cells express the pJ360 ahr-1:GFP fusion gene. At the 2-fold stage of embryogenesis, two cells express ahr-1:GFP in the tail, and the remaining fluorescing cells are in the forming head. During the first larval stage. ahr-1:GFP is expressed in 28 neurons, several blast cells, and two phasmid socket cells. The neurons that express ahr-1:GFP include ALNR/ALNL, AQR/PQR, AVM/PVM, BDUR/BDUL, PLMR/PLML, PLNR/PLNL, PHCL/PHCR, PVWL/PVWR, RMEL/RMER, SDQR/SDQL, and URXR/URXL. The T.pa, T.ppa, and T.ppp blast cells in the tail express ahr-1:GFP, as do all of their descendents, including the PHso1 and PHso2 phasmid socket cells. ahr-1:GFP is also expressed in the MI and I3 neurons in the pharynx and the G2 and W blast cells. Four additional cells in the head express ahr-1:GFP, tentatively identified as the ASK and RIP neurons.
• Subcellular Localization: The pJ360 construct includes the entire ahr-1 genomic sequence, and transgenic animals express this fusion protein in a subset of neuronal nuclei. The pHT102 transgene lacks most of the ahr-1 coding sequence and labels axons as well as nuclei.

• Primary Identifier: Expr15586

• Primary Identifier: Expr15651

• Primary Identifier: Expr15652

• Primary Identifier: Expr15589

• Primary Identifier: Expr15591

• Primary Identifier: Expr15598

• Primary Identifier: Expr15604

• Primary Identifier: Expr15608

• Primary Identifier: Expr11375
• Pattern: eat-4 is expressed in 78 of the 302 neurons of the adult hermaphrodite, which fall into 38 neuron classes (out of a total of 118 anatomically defined neuron classes in the hermaphrodite). Most of these neurons are either sensory- or interneurons. Only two motorneurons utilize glutamate; both are located in the pharynx.

• Primary Identifier: Expr15611

• Primary Identifier: Expr11016
• Pattern: Expression is first detected in 4 neuronal cells at around 350 min post-fertilization, which is the time at which the BAG and URX neurons are born. Expression is restricted to these 4 neurons during embryogenesis. At the first larval stage, egl-13 expression is observed in the BAG and URX neurons plus occasionally in a small number of unidentified cells in the head and tail (including the AQR and PQR neurons). Later during larval development, egl-13 expression is observed in body wall muscle and vulval cells (data not shown). Neuronal expression is restricted to the O2 and CO2-sensing neurons in the adult.

• Primary Identifier: Expr15359

• Primary Identifier: Expr15402

• Primary Identifier: Expr11367
• Pattern: SNF-3::GFP transgenic worms displayed strong expression in the excretory canal, tail hypodermal cells, epidermis and vulval epithelia cells. SNF-3 was also expressed in some neurons, including the excretory canal-associated neuron, and some sensory neurons in the head including ILs, OLs, ADE and AQR.

• Primary Identifier: Expr8589
• Remark: Picture: Figure 2C.
• Pattern: In first larval stage (L1) animals, GFP was expressed prominently in the URX and BAG sensory neurons, with weaker and inconsistent expression in the ASG and ADF sensory neurons, the pharynx, and a few intestinal cells. In older animals, GFP fluorescence was also observed in AQR and PQR sensory neurons.

• Primary Identifier: Expr9959
• Pattern: PDF-2::GFP signals could be observed throughout post-embryonic life. The PDF-2::GFP-expressing cells were identified as the interneurons BDUL/R, AVG, AIML/R, RIS, AVD and PVT, the chemosensory neuron pairs PHA and PHB, the motor neurons RID and RIML/R, the sensory neurons AQR and PQR, and less frequently in the PVPL/R interneurons. Outside the nervous system, strong expression was observed in rectal gland cells rectD and rectVL/R, the intestino-rectal valve cells virL/R and three posterior arcade cells in the head. Weak GFP fluorescence could also be observed in four additional head neurons that could not be unequivocally identified. GFP fluorescence was visible in neuronal cell bodies, axons and dendrites.

• Primary Identifier: Expr15570

• Primary Identifier: Expr15443

• Primary Identifier: Expr2987
• Remark: Reporter gene fusion type not specified.
• Pattern: Expression of gcy-35 was consistently observed in URX, AQR, and PQR sensory neurons; gcy-35 expression was also observed in ALN, SDQ and BDU neurons and variably in AVM, PLM and PLN neurons, pharyngeal and body wall muscles, and the excretory cell.

• Primary Identifier: Expr15644

0 Life Stages

5 Parents

Definition	Name	Synonym	Primary Identifier
neuron with its cell body situated in the head, excluding the pharynx.	head neuron		WBbt:0006751
post-embryonic cell of pedigree QR.a	QR.a		WBbt:0007279
neuron type, neurons that have ciliated nerve endings.	ciliated neuron		WBbt:0006816
neuron that has neural processes in the nerve ring.	nerve ring neuron		WBbt:0006974
Neuron that senses and responds to oxygen.	oxygen sensory neuron		WBbt:0008432